Croton zambesicus Root Extract Exert Laxative Effect in Rats
Jude E. Okokon, Augustine I. L. Bassey, Emmanuel E. Nyong, Utibe A. Edem
Asian Journal of Biology · pp. 22–26 · Published 29 Sep 2020
10.9734/ajob/2020/v10i230103Abstract
Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments. Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT). Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT. Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied. Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.
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