Antibiotic Resistance Profile of Bacterial Isolates Cultured from Urine Samples of HIV Seropositive Pregnant Women

Abstract

This study evaluated the antibiotic resistance pattern of some bacterial isolates cultured from urine samples of HIV seropositive pregnant women that attended antenatal clinic of the Ondo State Specialist hospital, Akure. The study determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of some antibiotics used against these bacterial isolates. The results showed the MIC and MBC values obtained for augmentin were found to be highest in Staphylococcus aureus (22.8 mg/mL) and lowest against Escherichia coli (1.43/2.85 mg/mL). The MIC and MBC values of all the antibiotics used against S. aureus isolates ranged from 0.004/0.008 mg/mL to 22.8 mg/mL. The MIC and MBC values of all the antibiotics tested against E. coli isolates ranged from 0.008/0.016 to 11.4/12.5 mg/mL, while the MIC and MBC values of all the antibiotics tested against Pseudomonas spp ranged from 0.391/0.781 mg/mL to 11.4/12.5 mg/mL. Among all the antibiotics used, ciprofloxacin was more effective against the bacterial isolates tested. The study concluded that most of the bacterial isolates cultured in this study were multi-resistant to different antibiotics tested in vitro.