Comparison of the Prognosis and Mortality of Sars-Cov-2 Variants in Critically İll Patients

Abstract

Backround: Since the beginning of the pandemic,the globally circulation of SARS-CoV-2 has caused the virus to constantly mutate,resulting in the emergence of new variants.Some of these variants have been designated as variants of concern(VOC),defined by the WHO as variants associated with increased infectivity,increased disease severity,or change in clinical disease presentation. Aim and Objective: We aimed  to evaluate and compare the prognosis and mortality of the critically ill patients infected with SARS-CoV-2 and SARS-CoV-2 variants. Materials and Methods: A total of 335 critically ill patient who were positive for SARS-CoV-2 by polymerase chain reaction enrolled in the study. Results: Hypertension was significantly higher in the patients in delta group(p=0,02).The presence of comorbidity was statistically significantly associated with mortality in all groups(p <0,05). Unvaccinated patients were significantly higher in all groups and being unvaccinated was associated with mortality in all groups(p <0,05).Mortality was statistically significantly associated with all groups(p=0,01).The delta variant poses a higher risk of mortality compared to other variants(p=0,0001). Conclusion: The study indicates that severe disease requiring intensive care admission were common in the elderly.Hypertension was higher in the patients in delta group and the presence of comorbidity was associated with mortality in all variant types of COVID-19.Severe disease requiring intensive care admission was more common in the unvaccinated population, regardless of variant type, and being unvaccinated was associated with mortality.All variant types were associated with mortality, but the mortality risk was higher in patients infected with delta variant compared to other variants.