Haematinic Effects of Aqueous Extract of Lophira lanceolata Leaves in Phenylhydrazine-induced Anaemia in Wistar Rats
Iserhienrhien Lucky Osafanme, Sheneni Victor Duniya, Nweje-Anyalowu Paul Chukwuemeka, Oguche Mercy, Idakwoji Precious Adejoh
Asian Journal of Research in Biochemistry · pp. 1–6 · Published 22 Feb 2019
10.9734/ajrb/2019/v4i130057Abstract
Aim: The haematinic activity of the aqueous extract of Lophira lanceolata leaves was investigated using rat model of phenylhydrazine-induced anaemia. Methods and Results: Red Blood Cell (RBC) count, Haemoglobin (Hb) concentration and Packed Cell Volume (PCV) were analysed as indices of anaemia. Following phenylhydrazine administration to rats at a dose of 10 mg/kg for 8 days, a significant decrease (P<0.05) in the haematological parameters was observed indicating anaemia. However, treatment with graded doses (200, 400 and 800 mg/kg) of the aqueous extract of Lophira lanceolata leaves produced a significant (P<0.05) increase in the RBC count, Hb concentration and PCV time- and dose- dependently. Conclusion: It was concluded that Lophira lanceolata leaves possess haematinic activity, making it useful in the management of anaemia.
Cited by 5
Coralia Cotoraci, Alina Ciceu, Alciona Sasu · International Journal of Molecular Sciences · 2021
Ernest Atelhe Amama, Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria, Augustine Lishilinimye Udefa · Physiology and Pharmacology · 2021
Wawa Justine Tiepka, N'guessan Alain Yao, Kouakou S. Konan · International Journal of Basic & Clinical Pharmacology · 2025
Pawendé Kabré, Lassina Ouattara, Yacouba Sanou · Scientific African · 2023
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