High Dose-Short Duration Therapy of Cholecalciferol as a New Therapeutic Approach in the Treatment of Chronic Low Back Pain Associated with Vitamin D Deficiency

Abstract

Chronic low back pain (CLBP) is a significant health issue, often linked to widespread vitamin D deficiency, particularly in Indian populations where prevalence exceeds 70%. This review evaluates the efficacy and safety of Oral Cholecalciferol Nano-Syrup therapy of High-Dose, Short-Duration (60,000 IU/day for 10 days) versus Conventional Weekly Vitamin D supplementation (60,000 IU/week for 12 Week) for the treatment of Vitamin D deficiency associated with Chronic Low Back Pain. While weekly regimens achieve vitamin D sufficiency rates of 44–68%, the High-Dose, Short-Duration therapy of Nano-syrup therapy consistently attains 100% sufficiency within 10 days, alongside marked improvements in Visual Analog Scale (VAS) and Modified Oswestry Disability Questionnaire (MODQ) scores, with reductions of up to 75% and 40%, respectively. The High-Dose, Short-Duration approach also demonstrated a favorable safety profile, with no serious adverse events reported. These findings suggest that high-dose, short-duration vitamin D therapy offers a more effective and efficient alternative for managing vitamin D deficiency and associated CLBP, highlighting its potential for broader clinical application.