1,3,4-Thiadiazole Derivatives as an Antimicrobial:  An Update

Harigopal S. Sawarkar; Mahavir Singh; Birendra Shrivastav; R. L. Bakal

doi:10.9734/jpri/2021/v33i62A35203

Research Article Open access CC BY 4.0

1,3,4-Thiadiazole Derivatives as an Antimicrobial: An Update

Harigopal S. Sawarkar, Mahavir Singh, Birendra Shrivastav, R. L. Bakal

Journal of Pharmaceutical Research International · pp. 232–257 · Published 28 Dec 2021

10.9734/jpri/2021/v33i62A35203

Abstract

Persistent and uncontrolled use of antibiotics results in development of bacterial resistant. The situation is getting worsen day by day and scientists are investigating thousands of potentially active drugs like molecule in laboratories around the world every day in search of effective antibiotics. During last decade considerable attention was given to five-member heterocyclic moieties while designing new antimicrobial agents. One of important heterocycle is five-membered 1,3,4-thiadiazole with unique bioisosteric properties displaying unusually wide spectrum of biological activities. This comprehensive review represent the recent 1,3,4-thiadiazole and its derivatives, which can be considered as potential antimicrobial agents in the period of 2015 and onwards. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects.

1,3,4-thiadiazole anti-tubercular activity antimicrobial activity thiadiazole

Cited by 0

No indexed citations yet.

In vitro Antibacterial and Antitubercular Activities of Leaf Extracts of Senna occidentalis — shares topic coverage
Synthesis, Characterization and Evaluation of Anti-tubercular Activity of Ofloxacin Chalcone Conjugates — shares topic coverage
Synthesis of [Oxa-, Thia-diazoles- and Triazole]-Thiols Derived from Butyric Acid: Conductivity Property, Complex Formation with Fe (II), Hg (II), and Synthesis of Seco-Acyclo-S-Glycosides — shares topic coverage
Structural and Solvent Dependence of the Electronic Properties and Corrosion Inhibitive Potentials of 1,3,4-thiadiazole and Its Substituted Derivatives- A Theoretical Investigation — shares topic coverage
Influential Cooperation between Zeolite and PGPR on Yield and Antimicrobial Activity of Thyme Essential Oil — shares topic coverage

Access this article

View at publisher

Cite this article

Harigopal S. Sawarkar, Mahavir Singh, Birendra Shrivastav, R. L. Bakal (2021). 1,3,4-Thiadiazole Derivatives as an Antimicrobial: An Update. Journal of Pharmaceutical Research International , 232–257. https://doi.org/10.9734/jpri/2021/v33i62A35203

Affiliations

Harigopal S. Sawarkar — Dr. Rajendra Gode College of Pharmacy, Amravati, Maharashtra, India.
Mahavir Singh — School of Pharmacy, Jaipur National University, Jaipur, Rajasthan, India.
Birendra Shrivastav — School of Pharmacy, Jaipur National University, Jaipur, Rajasthan, India.
R. L. Bakal — Dr. Rajendra Gode College of Pharmacy, Amravati, Maharashtra, India.

Metrics

5
Views: 0
Downloads: 0
Citations: 1
Outbound

Full metrics

Article metrics

Real usage data collected on this platform.

5

Page views

0

PDF downloads

1

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.