Effect of Morinda Lucida Leaf Extract on Ibuprofen Induced Nephrotoxicity Albino Rats
Nkiruka Millicent Amadi, Peter Uwadiegwu Achukwu, Emmanuel Ifeanyi Obeagu, Nonyelum V. Anoh
Asian Journal of Medical Principles and Clinical Practice · pp. 236–242 · Published 12 Oct 2021
Abstract
Morinda lucida ethanol stem bark extract dilution of ((500, 1000, 1500) mg /kg) body weight were administered to B1, B2, B3 groups subjected to ibuprofen induced nephrotoxicity. Histomorphological studies on target organ; kidney were harvested, weighed and processed. Ibuprofen toxic activities of the extracts treated groups (serum biochemical markers) and the relative organ index (ρ<0.05) in treated groups respectively produce significant changes. Target organ extract examinations offered some protection on glomerular and tubular degenerative changes while there are deterioration changes in B groups.
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