A Study of the Inclusion Complex Formed Between Cucurbit[8]uril and N,4-Di(pyridinyl)benzamide Derivative
Zhikang Wang, Mingjie Yang, Weibo Yang, Zhongzheng Gao, Hui Zhao, Gang Wei, Jifu Sun
Organics · pp. 26–26 · Published 17 Jun 2025
10.3390/org6020026Abstract
The interaction between cucurbit[8]uril (Q[8]) and the guest 1-methyl-4-(4-(1-methylpyridin-1-ium-4-yl)benzamido)pyridin-1-ium (PB2+) has been thoroughly investigated. Multiple techniques were employed, including 1H NMR spectroscopy, mass spectrometry, isothermal titration calorimetry (ITC), UV–vis absorption spectrophotometry, and quantum chemistry calculations. The experimental results and calculation analysis have clearly shown that in aqueous solution, the host Q[8] preferentially encapsulates the phenylpyridinium salt moiety of the PB2+ guest within its hydrophobic cavity, forming a 1:2 inclusion complex.
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Prabukumar Balakrishnan, Venkatakrishnan Parthasarathy · Journal of Materials Chemistry C · 2026
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