The Synthesis of Atomoxetine-containing Carboxamides - Potential Human Carbonic Anhydrase Inhibitors
Anton A. Shetnev, Angelina T. Osipyan, Alexander V. Sapegin, Mikhail V. Dorogov
Chemical Science International Journal · pp. 1–5 · Published 23 Oct 2015
10.9734/ACSJ/2016/22245Abstract
The method of synthesis of Atomoxetine is developed, including enzyme-catalyzed stereospecific reduction 3-chloro-1-phenyl-propan-1-one and Mitsunobu condensation with a chiral alcohol, and o-cresol. New potential human carbonic anhydrase inhibitors were obtained via reaction Atomoxetine with carboxylic derivatives of benzene and thiophene containing primary sulfonamide moiety.
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