Skip to content
Research Article Open access CC BY 4.0

Trends of Antibacterial Interactions in Multidrug – Resistant Isolates: Exploring Resistance Phenotypes in the Ndé Division, West-Cameroon

Vanessa Ornella Alactio Tangueu, O’Neal Dorsel Youté, Blandine Pulcherie Tamatcho Kweyang, Vanessa Flora Yomi Nana, Pierre René Fotsing Kwetche

Microbiology Research Journal International · pp. 9–22 · Published 13 Mar 2024

10.9734/mrji/2024/v34i21427

Abstract

Background: Reliable pieces of information concerning bacterial-antibiotic interactions are key assets for therapeutic management of bacterial diseases. Objective: The present study aimed at detecting phenotypic characteristics of bacterial resistance in multidrug-resistant isolates recovered from clinical specimens at the “Université des Montagnes” Teaching Hospital. Methods: The total of 226 isolates (142 Gram-negative rods and 84 Gram-positive cocci) were subjected to phenotypic screening of resistance mechanisms. All procedural steps were conducted according to standard protocols on bacterial susceptibility to antibiotics. Results: Primary pieces of information revealed high rates of resistant isolates, especially with beta-lactams and Trimethoprim/Sulfamethoxazole while Nitrofurantoin and Imipenem were most effective. Amongst Gram-negative rods, 56% expressed one enzymatic resistance mechanism and 12% expressed two against beta-lactams. Also, with extended spectrum beta-lactamases, high level cephalosporinases and inducible cephalosporinases most commonly observed. About 62% and 14% of Gram-positive cocci expressed constitutive and Clindamycin-inducible resistance, respectively. Decreased susceptibility to Ceftriaxone and Penicillin G was also recorded in suspect mutant isolates selected by these antibiotics. Potential synergetic and other antagonistic interactions were evenly detected. Conclusion: Overall, the data could represent reliable clue for advocacy about personalized combination therapy, then capacity building for routine affordable susceptibility tests in caretaking.

Antibiotics combination bacteria multidrug-resistant resistance mechanisms

References (24)

  1. 1 Induced root-secreted phenolic compounds as a belowground plant defense [DOI]
  2. 2 Selection of Resistant Bacteria at Very Low Antibiotic Concentrations [DOI]
  3. 3 Antimicrobial Resistance: a One Health Perspective [DOI]
  4. 4 Antibiotic Resistance: One Health One World Outlook [DOI]
  5. 5 Emergence and spread of antibiotic resistance following exposure to antibiotics [DOI]
  6. 6 Evolutionary Trajectories to Antibiotic Resistance [DOI]
  7. 7 Cephalosporin and fluoroquinolone combinations are highly associated with CTX-M β-lactamase-producing Escherichia coli: a case–control study in a French teaching hospital [DOI]
  8. 8 Burden of Antibiotic Resistance in Common Infectious Diseases: Role of Antibiotic Combination Therapy [DOI]
  9. 9 The economic burden of antimicrobial resistance: Why it is more serious than current studies suggest [DOI]
  10. 10 Évaluation du pouvoir antimicrobien des huiles essentielles de sept plantes médicinales récoltées au Maroc [DOI]
  11. 11 Antimicrobial resistance and One Health [DOI]
  12. 12 One Health—One Biofilm [DOI]
  13. 13 Combination Effect of Ciprofloxacin and Gentamicin against Clinical Isolates of Salmonella enterica Serovar Typhi with Reduced Susceptibility to Ciprofloxacin [DOI]
  14. 14 Antibiotic exposure as a risk factor for emergence of resistance: the influence of concentration [DOI]
  15. 15 Antimicrobial resistance of Gram-negative bacilli isolates from inpatients and outpatients at Yaounde Central Hospital, Cameroon [DOI]
  16. 16 Nitrofurantoin Combined With Amikacin: A Promising Alternative Strategy for Combating MDR Uropathogenic Escherichia coli [DOI]
  17. 17 Combination versus monotherapy for the treatment of infections due to carbapenem-resistant Enterobacteriaceae [DOI]
  18. 18 Inducible and constitutive clindamycin resistance in Staphylococcus aureus in a northeastern Indian tertiary care hospital [DOI]
  19. 19 Investigation of inducible clindamycin and telithromycin resistance in isolates of β-hemolytic streptococci [DOI]
  20. 20 Multicenter study on antibiotic susceptibility/resistance trends in the western region of Cameroon [DOI]
  21. 21 Characterization of Clinically Isolated Antibiotic-Resistant Salmonella Typhimurium Exposed to Subinhibitory Concentrations of Ceftriaxone and Ciprofloxacin [DOI]
  22. 22 Piperacillin plus aztreonam for treatment of neutropenic fever [DOI]
  23. 23 ANTIBIOTIC SUSCEPTIBILITY/RESISTANCE PROFILE OF BACTERIA FROM FARM WASTES: FINDINGS IN EXCRETA FROM FOUR POULTRIES OF WEST CAMEROON
  24. 24 Self-medication among inhabitants of Yaounde, Cameroon: Pull and push factors [DOI]

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

26

Page views

0

PDF downloads

35

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.