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Research Article Open access CC BY 3.0

Toxicological Impact of Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on Some Hormonal Profiles and Hematological Parameters in Goats

Azza M. Mohamed, A. O. Hegab, Jehad M. Yousef, Manal E. A. El H alwagy

Annual Research & Review in Biology · pp. 1278–1289 · Published 2 Jan 2014

10.9734/ARRB/2014/6614

Abstract

Female Baladi goats were used to investigate the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on some serum hormones and blood features. Animals were divided into two groups, group 1: served as control, group 2: animals were orally administered with three repeated doses (0.23µg/Kg body weight) of TCDD with 2 days interval between dosing. Results revealed that exposure to TCDD induced reduction in serum estradiol, progesterone and prolactin levels and elevation in glucocorticoid hormone cortisol throughout the different studied periods (48h, 96h and 16 days commenced the last intoxicated dose). The adverse impact of TCDD on goat reproductive hormones was confirmed by histopatholgical observations on their uteri and ovaries after 16 days commenced the last intoxicated dose. Intoxication of goats with TCDD showed also marked decreases in hemoglobin (Hb) concentration, red blood cell count (RBC), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentrations (MCHC) compared with normal healthy group. Pronounced decreases in total white blood cells (WBC) count as well as in its differential percentages namely lymphocytes, monocytes and eosinophils were also noticed in intoxicated animals compared with normal ones, while the percentage of neutrophils showed significant increase. In conclusion, the results of this study indicated that oral exposure of female goats to repeated doses of TCDD caused endocrine disruption which may lead to adverse impact on their reproductive performance. Moreover, toxicity of TCDD induced immunosuppressive effect and anemia as indicated by its deleterious action on different hematological parameters.

Female goats tetrachlorodibenzo-p-dioxin hormones hematological parameters.

References (41)

  1. 1 Theory and Practice of Histological Techniques
  2. 2 2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity [DOI]
  3. 3 Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice [DOI]
  4. 4 Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats [DOI]
  5. 5 Endocrine Control of Osmoregulation in Teleost Fish1 [DOI]
  6. 6 Modulation of oestrogen receptor signalling by association with the activated dioxin receptor [DOI]
  7. 7 Statistical Methods (7th ed.)
  8. 8 Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin [DOI]
  9. 9 Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models. [DOI]
  10. 10 Endocrine Disruptors: Can Biological Effects and Environmental Risks Be Predicted? [DOI]
  11. 11 Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds [DOI]
  12. 12 The mechanism of dioxin toxicity: relationship to risk assessment. [DOI]
  13. 13 Exposure to TCDD During Development Permanently Alters Reproductive Function in Male Long-Evans Rats and Hamsters: Reduced Ejaculated and Epididymal Sperm Numbers and Sex Accessory Gland Weights in Offspring with Normal Androgenic Status [DOI]
  14. 14 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition [DOI]
  15. 15 Osmoregulatory Actions of Growth Hormone and Prolactin in an Advanced Teleost [DOI]
  16. 16 Environmental contaminant–mixture effects on CNS development, plasticity, and behavior [DOI]
  17. 17 Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary [DOI]
  18. 18 PCB126 Induces Differential Changes in Androgen, Cortisol, and Aldosterone Biosynthesis in Human Adrenocortical H295R Cells [DOI]
  19. 19 Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Female Rats: Ovulation, Hormonal Regulation, and Possible Mechanism(s) [DOI]
  20. 20 TCDD Treatment Eliminates the Long-Term Reconstitution Activity of Hematopoietic Stem Cells [DOI]
  21. 21 Hemopoietic Progenitor Cells Are Sensitive Targets of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in C57BL/6J Mice [DOI]
  22. 22 Assessing Forest Fire as a Potential PCDD/F Source in Queensland, Australia [DOI]
  23. 23 Subchronic/Chronic Toxicity of a Mixture of Four Chlorinated Dibenzo-p-dioxins in Rats [DOI]
  24. 24 Subchronic/Chronic Toxicity of a Mixture of Four Chlorinated Dibenzo-p-dioxins in Rats [DOI]
  25. 25 The early embryo loss caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin may be related to the accumulation of this compound in the uterus [DOI]
  26. 26 Biologically Based Pharmacodynamic Models: Tools for Toxicological Research and Risk Assessment [DOI]
  27. 27 Carbohydrate Effect: Hormone and Oxidative Changes [DOI]
  28. 28 Mechanisms of Gender-specific TCDD-induced Toxicity in Guinea Pig Adipose Tissue 11The work was supported in part by National Institutes of Health Grants ES 08585, P01 ES06198, and P30 ES05707 and by Grant number 3PB-0095 from the University of California Breast Cancer Research Program, Cycle III. [DOI]
  29. 29 Tampons, dioxins, and endometriosis [DOI]
  30. 30 Short-Term Variations of Biochemical Parameters in Racing Pigeons (Columba livia) [DOI]
  31. 31 Effects of2,3,7,8-tetrachlorodibenzo-p-dioxin on blood and spleen natural killer (NK) cell activity in the mouse [DOI]
  32. 32 The Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Corticotrophin-Releasing Hormone, Arginine Vasopressin, and Pro-opiomelanocortin mRNA Levels in the Hypothalamus of the Cynomolgus Monkey [DOI]
  33. 33 The Regulation of Prolactin Cells in the Rainbow Trout (Oncorhynchus mykiss) [DOI]
  34. 34 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor [DOI]
  35. 35 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Alterations in Lymphocyte Development and Thymic Atrophy in Hemopoietic Chimeras Generated from Mice Deficient in ARNT2 [DOI]
  36. 36 Impaired ovulation by 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in immature rats treated with equine chorionic gonadotropin [DOI]
  37. 37 Effect of dioxin on ovarian function in the cynomolgus macaque (M. fascicularis) [DOI]
  38. 38 In Ovo2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure in Three Avian Species [DOI]
  39. 39 Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in immature male and female chickens [DOI]
  40. 40 Effects of a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin, given at post-puberty, in senescent mice [DOI]
  41. 41 [Are dioxins a health problem in Finland?].

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