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Research Article Open access CC BY 3.0

The Role of Propolis in Inflammation and Orofacial Pain: A Review

Merlini Rajoo, Abhishek Parolia, Allan Pau, Fabian Davamani Amalraj

Annual Research & Review in Biology · pp. 651–664 · Published 13 Nov 2013

10.9734/ARRB/2014/6111

Abstract

In recent years, the use of natural products and holistic or alternative medicine has gained popularity among the public, due to the potential side effects and safety concerns of conventional allopathic formulations. Natural products have been used since ancient times in folk medicine, involving both eastern and western traditional medicine. Among these natural products, a resinous bee product named propolis has gained popularity. It has been reported to have anti-inflammatory, anti-bacterial, anti-fungal, anti-viral, anti-oxidant and anti-cancer properties. Due to these properties there has been an increasing interest in the use of bee propolis in contemporary dentistry. In dentistry propolis has been tried out almost in every field such as to treat oral cancer, recurrent ulcers, fungal infections, in restorative dentistry as a cariostatic, desensitizing and pulp capping agent, in endodontics as an intra-canal medicament, intra-canal irrigant, in dental trauma as a storage media for an avulsed tooth, in oral surgery to treat dry socket after tooth extraction, in prosthetics to treat denture stomatitis, in periodontics to treat gingivitis, periodontitis and to control bone resorption. Despite having numerous advantages and uses, the role of propolis in orofacial pain is probably the least understood. Hence, this review highlights the anti-inflammatory and pain relieving mechanisms of propolis at the molecular level in orofacial pain.

Propolis anti-inflammatory orofacial pain analgesic effect

References (46)

  1. 1 The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms [DOI]
  2. 2 Wound healing: an overview of acute, fibrotic and delayed healing [DOI]
  3. 3 Propolis: chemical composition, biological properties and therapeutic activity [DOI]
  4. 4 Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. [DOI]
  5. 5 Propolis : a review
  6. 6 Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs [DOI]
  7. 7 The effect of propolis and its components on eicosanoid production during the inflammatory response [DOI]
  8. 8 Phytochemical compounds involved in the anti-inflammatory effect of propolis extract [DOI]
  9. 9 Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products [DOI]
  10. 10 The etiology of temporomandibular disorders: implications for treatment.
  11. 11 Peripheral and central mechanisms of orofacial inflammatory pain [DOI]
  12. 12 Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models [DOI]
  13. 13 A comparative histological analysis of human pulp following direct pulp capping with Propolis, mineral trioxide aggregate and Dycal [DOI]
  14. 14 Propolis and its potential uses in oral health [DOI]
  15. 15 Propolis: a review of its anti-inflammatory and healing actions [DOI]
  16. 16 Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-κB Transcription Factors [DOI]
  17. 17 Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages [DOI]
  18. 18 The effect of bee propolis on recurrent aphthous stomatitis: a pilot study [DOI]
  19. 19 Peripheral and central sensitization in musculoskeletal pain disorders: An experimental approach [DOI]
  20. 20 Propolis and Some of its Constituents Down-Regulate DNA Synthesis and Inflammatory Cytokine Production but Induce TGF-β1 Production of Human Immune Cells [DOI]
  21. 21 A Study on Flavonoids of Propolis [DOI]
  22. 22 Analytical methods applied to diverse types of Brazilian propolis [DOI]
  23. 23 Bulgarian Propolis Induces Analgesic and Anti-inflammatory Effects in Mice and Inhibits In Vitro Contraction of Airway Smooth Muscle [DOI]
  24. 24 Etiology of temporomandibular disorders: implications for treatment [DOI]
  25. 25 Anti-inflammatory activity of propolis extracts: a review [DOI]
  26. 26 Brazilian Green Propolis Inhibits Inflammatory Angiogenesis in a Murine Sponge Model [DOI]
  27. 27 Does Propolis Help to Maintain Oral Health? [DOI]
  28. 28 Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock [DOI]
  29. 29 Protective effects of Chinese and Brazilian propolis treatment against hepatorenal lesion in diabetic rats [DOI]
  30. 30 Effect of Brazilian propolis on sneezing and nasal rubbing in experimental allergic rhinitis of mice [DOI]
  31. 31 Mechanism-based classification of pain for physical therapy management in palliative care: A clinical commentary [DOI]
  32. 32 Care seeking for orofacial pain.
  33. 33 Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca2+ and Differentially Interact with Platelet-Type 12-Lipoxygenase [DOI]
  34. 34 Systemic Contact Dermatitis from Propolis Ingestion [DOI]
  35. 35 Propolis effects on pro-inflammatory cytokine production and Toll-like receptor 2 and 4 expression in stressed mice [DOI]
  36. 36 Standardized propolis extract and calcium hydroxide as pulpotomy agents in primary pig teeth.
  37. 37 Effect of Egyptian Propolis on the Susceptibility of LDL to Oxidative Modification and its Antiviral Activity with Special Emphasis on Chemical Composition [DOI]
  38. 38 Pain Management Part II: Pharmacologic Management of Chronic Orofacial Pain [DOI]
  39. 39 Allergic contact cheilitis and perioral dermatitis caused by propolis: case report.
  40. 40 High-performance liquid chromatographic analysis of flavonoids from propolis [DOI]
  41. 41 Analgesic effect of Anatolian propolis in mice.
  42. 42 Hive Products: Pollen, Propolis and Royal Jelly [DOI]
  43. 43 MAST CELL POPULATION ON ORAL ULCERS OF RATS TREATED BY BRAZILIAN PROPOLIS
  44. 44 Effects of Turkish propolis and silver sulfadiazine on burn wound healing in rats
  45. 45 Dermatite atópica: uma doença cutânea ou uma doença sistêmica? A procura de respostas na história da dermatologia [DOI]
  46. 46 Composition and physico-chemical properties of propolis.

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