Sex Hormones and Their Relationship with Leptin and Cardiovascular Risk Factors in Pre and Post-Menopausal Nigerian Women with Metabolic Syndrome
U. A. Fabian, M. A. Charles-Davies, A. A. Fasanmade, J. A. Olaniyi, O. E. Oyewole, M. O. Owolabi, J. R. Adebusuyi, O. Hassan, B. M. Ajobo, M. O. Ebesunun, K. Adigun, K. S. Akinlade, O. G. Arinola, E. O Agbedana
Cardiology and Angiology: An International Journal · pp. 149–156 · Published 15 Apr 2015
10.9734/CA/2015/15236Abstract
Metabolic Syndrome (MS), which affects 33.1% of Nigerians, predisposing them to cardiovascular disease (CVD) risk, has been associated with the female gender. The cardioprotective effect of oestradiol against CVD is now controversial and was investigated in premenopausal with MS (PRMMS) and postmenopausal women with MS (POMMS). A total of 191 women (44 PRMMS, 126 POMMS and 21 premenopausal women without MS (PRM) (controls) with mean (s.d) age of 40.0 (6.9), 57.0 (8.8), 29.0 (6.8) years were participants of this study. Demography, blood pressure (BP), anthropometry, hormones, fasting plasma glucose (FPG) and lipids were obtained by standard methods. Data were significant at (P<.05). Age, parity, all anthropometric measures, FPG, leptin, ET ratio and FSH were significantly higher while HDLC, testosterone and prolactin were significantly lower in PRMMS compared with controls (P<.03). In comparison of POMMS with PRMMS, age, parity, WHR, systolic BP, TG, FSH and LH were significantly higher while body weight, HC, and leptin were lower in POMMS compared with PRMMS (P<.05). DBP positively predicted oestradiol in PRM only (P=.044) while oestradiol positively predicted testosterone in PRMMS only (P<.001). In POMMS only, DBP positively predicted testosterone; testosterone, ET ratio and FSH positively predicted oestradiol while LDLC and oestradiol positively predicted the ET ratio (P<.03). Metabolic syndrome may predispose both pre and postmenopausal women to the risk cardiovascular disease and type 2 diabetes mellitus. Oestradiol may protect against cardiovascular diseases in women without metabolic syndrome only.
References (27)
- 1 International Diabetes Federation 2017 [DOI]
- 2 The IDF consensus worldwide definition of the metabolic syndrome [DOI]
- 3 Hormonal Changes in the Menopause Transition [DOI]
- 4 Inflammation as a Link between Obesity and Metabolic Syndrome [DOI]
- 5 Dietary Intake of Carotenoids and Their Antioxidant and Anti-Inflammatory Effects in Cardiovascular Care [DOI]
- 6 Metabolic syndrome after menopause and the role of hormones [DOI]
- 7 Prevalence and gender distribution of the metabolic syndrome [DOI]
- 8 Management of cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynaecologists [DOI]
- 9 Cardiovascular risk in menopausal women and prevalent related co-morbid conditions: facing the post-Women's Health Initiative era [DOI]
- 10 A Comparative Study of Lipid Profile and Oestradiol in Pre- and Post-Menopausal Women [DOI]
- 11 Influence of Sex Hormones and Phytoestrogens on Heart Disease in Men and Women [DOI]
- 12 Ovarian Hormone Status and Abdominal Visceral Adipose Tissue Metabolism [DOI]
- 13 Effect of Age at Menopause on Blood Pressure in Postmenopausal Women [DOI]
- 14 The effects of menopause on the serum lipid profile of normal females of South East Nigeria.
- 15 Unravelling the cardioprotective mechanism of action of estrogens [DOI]
- 16 Changes in lipid profile of postmenopausal women.
- 17 Serum lipids, blood pressure and body weight around the age of the menopause [DOI]
- 18 SERUM TESTOSTERONE AND LIPIDS IN RELATION TO SEXUAL DYSFUNCTION IN MALES WITH METABOLIC SYNDROME AND TYPE2 DIABETES MELLITUS
- 19 Metabolic Alterations in Different Stages of Hypertension in an Apparently Healthy Nigerian Population [DOI]
- 20 Systemic Vascular Hemodynamic Changes due to 17-β-Estradiol Intranasal Administration [DOI]
- 21 Effects of exercise training on postmenopausal hypertension: implications on nitric oxide levels.
- 22 Testosterone and Cardioprotection Against Myocardial Ischemia [DOI]
- 23 Impact of Dietary Intervention on Selected Biochemical Indices of Inflammation and Oxidative Stress in Nigerians with Metabolic Syndrome: A Pilot Study [DOI]
- 24 Prevalent Components of Metabolic Syndrome and Their Correlates in Apparently Healthy Individuals in Sub-saharan Africa [DOI]
- 25 Harnessing Hormonal Signaling for Cardioprotection [DOI]
- 26 Anthropometric and metabolic indicators in hypertensive patients.
- 27 International Journal of Medicine and Medical Sciences [DOI]
Cited by 5
Olulope O. Ajayi, Mabel A. Charles-Davies, John I. Anetor, Adeyinka F. Ademola · Journal of Cancer and Tumor International · 2016
O. O. Ajayi, O. R. Akerele · Journal of Applied Sciences and Environmental Management · 2025
I. Famuyiwa O., P. Bitrus D., A. Charles-Davies M. · International Journal of Medicine and Medical Sciences · 2016
Showing 3 of 5 known citations — external sources report more than can currently be individually listed.
Related research
- Metabolic Syndrome among Healthcare Workers in a Tertiary Hospital in South-South, Nigeria — shares topic coverage
- Cortisol and Metabolic Syndrome Components in Obese and Overweight Young Adults of a Nigerian Private University — shares topic coverage
- Metabolic Syndrome and Kidney Damage: Prevalence and Assessment of Risk among Apparently Healthy Resident of Ado Ekiti, South West Nigeria — shares topic coverage
- Vitamin D and Insulin Resistance in Metabolic Syndrome — shares topic coverage
- Metabolic Syndrome and Its Association with Nutritional and Cardiometabolic Risk Factors: Prevalence among Apparently Healthy Adults in a Rural Community in Southwestern Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
67
Page views
0
PDF downloads
18
Outbound clicks
5
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.