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Serum Polyunsaturated Fatty Acid Profile and Carotid Intima-media Thickness in Japanese Atherosclerotic Patients Hospitalized for Endovascular Therapy

Hisataka Nakamura, Keita Odashiro, Masahiko Fujihara, Mitsuhiro Fukata, Takeshi Arita, Taku Yokoyama, Shioto Yasuda, Toru Maruyama, Koichi Akashi

Cardiology and Angiology: An International Journal · pp. 1–9 · Published 11 May 2016

10.9734/CA/2016/26017

Abstract

Aims: Serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio (EPA/AA) in Japanese is rapidly changing according to the senescence and food westernization, and sonographic carotid artery intima-media thickness (IMT) is increasingly used as a surrogate of systemic atherosclerosis. However, the relationship between IMT and EPA/AA in Japanese remains unclear. Place of the Study: Vascular Laboratory of Heart Center, Kyushu University Hospital, Fukuoka, Japan. Methodology: Seventy consecutive Japanese atherosclerotic patients (69.7±7.8 years) hospitalized for elective endovascular therapy without purified EPA agent administration were enrolled in this study. IMT was estimated by high-resolution duplex ultrasonography in vascular laboratory. Conventional vascular risk factors were under the intensive treatment. Demographic variables were extracted from medical records after obtaining informed consent. Results: IMT was strongly age-dependent (P = .003) and age-adjusted multiple correlation analyses revealed no significant correlations among vascular risk factors, although positive partial correlation between serum EPA/AA and IMT (r = .277, P = .056) and negative partial correlation between EPA/AA and HbA1c (r = -.281, P = .053) were marginal. Stepwise multiple regression analyses demonstrated age and serum EPA/AA as positive contributors to the IMT (P < .001). EPA/AA was a seemingly paradoxical positive contributor to IMT due to age-dependent complicated profile of EPA/AA. Multiple correlation analyses were performed by multiple adjustments, which yielded significant negative correlation between EPA/AA and IMT (r = -.262,               P = .049). Conclusions: This study demonstrated that EPA/AA is a determinant of IMT among other vascular risk factors at least in Japanese atherosclerotic patients hospitalized for endovascular therapy.  

Atherosclerosis carotid artery eicosapentaenoic acid intima-media thickness

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