Research Progress on the Role of Inflammation in Kawasaki Disease
Li Huirong, Jia Kunpeng, Gao Chunyan, Jiao Fuyong
Asian Journal of Pediatric Research · pp. 60–66 · Published 21 Sep 2023
10.9734/ajpr/2023/v13i3281Abstract
As the pathogenesis of Kawasaki disease continues to evolve, researchers have proposed a number of hypotheses, from viral infections, genetic and environmental influences, to toxin-mediated autoinflammatory responses.More and more attention has been paid to the role of inflammation in KD (Kawasaki disease) pathogenesis.Objective: To explore the role of inflammation in Kawasaki disease and to provide a new idea for the diagnosis and treatment of KD.Methods: A systematic search was conducted from PubMed and CNKI databases (last updated on March 31, 2023) for relevant and qualified articles evaluating the role of inflammation in KD. Results: The research results of the last five years were selected from these articles for meta-analysis.Conclusion: Through comprehensive analysis, we conclude that inflammatory response is the main process of vascular damage in Kawasaki disease, especially the NLRP3 inflammasome which plays an important role.However, the etiology and pathogenesis of KD are very complex, and inflammation is only one manifestation. More and more studies have shown that inflammation plays a crucial role in the pathogenesis of Kawasaki disease, which has been recognized,and we comprehensively describe some important roles and latest research perspectives of inflammation in Kawasaki disease.
References (20)
- 1 Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling [DOI]
- 2 Inflammatory caspases are innate immune receptors for intracellular LPS [DOI]
- 3 Kawasaki Disease [DOI]
- 4 B cells in the pathogenesis of primary Sjögren syndrome [DOI]
- 5 Kawasaki disease: pathophysiology and insights from mouse models [DOI]
- 6 Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation [DOI]
- 7 Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases [DOI]
- 8 Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases [DOI]
- 9 Histopathological aspects of cardiovascular lesions in Kawasaki disease [DOI]
- 10 Pathogenesis of Kawasaki disease [DOI]
- 11 TIFA as a crucial mediator for NLRP3 inflammasome [DOI]
- 12 Temporal and geographical clustering of Kawasaki disease in Japan: 2007–2012 [DOI]
- 13 Phase I/IIa Trial of Atorvastatin in Patients with Acute Kawasaki Disease with Coronary Artery Aneurysm [DOI]
- 14 The role of mitochondria in the pathogenesis of Kawasaki disease [DOI]
- 15 Altered immunoglobulin A and M levels associated with changes in BAFF and APRIL after administration of intravenous immunoglobulin to treat Kawasaki disease.
- 16 Distinct variations of antibody secreting cells and memory B cells during the course of Kawasaki disease [DOI]
- 17 Inositol-Triphosphate 3-Kinase C and DNA Methylation Involvement in NLRP3 Inflammasome Activation in Kawasaki Disease [DOI]
- 18 Association of ITPKC gene polymorphisms rs28493229 and rs2290692 in North Indian children with Kawasaki disease [DOI]
- 19 [Expression of Nod-like receptor protein 3 inflammasome in peripheral blood mononuclear cells of children with Kawasaki disease in the acute stage]. [DOI]
- 20 Changes in BAFF/APRIL levels in a 2-year-old girl with Kawasaki disease refractory to intravenous immunoglobulin therapy.
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