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Research Article Open access CC BY 4.0

Progress of Animal Experimental Research on the Effect of Stem Cells on Coronary Artery Lesion in Kawasaki Disease

Zhilong Mu, Na Gao, Ting Dai, Xiaoyan Huang, Cuixiang Xu, Xianpeng Yan, Hua Guo, Fuyong Jiao

Asian Journal of Pediatric Research · pp. 40–46 · Published 5 Dec 2022

10.9734/ajpr/2022/v10i4205

Abstract

Kawasaki disease (KD) is an acute, febrile, erupting, self-limited autoimmune disease with systemic vasculitis as the main lesion. It is more common in children under 5 years old, and the main lesions associate the coronary arteries. With the increasing incidence, it has become the first cause of acquired heart disease in children. There are many basic and clinical studies on Kawasaki disease at home and abroad, but there are few animal experimental studies on the treatment of coronary artery injury with stem cells. Therefore, it is of great value to select scientific experimental animal models for Kawasaki disease research to simulate the human characteristics of Kawasaki disease. Through the establishment and in-depth study of animal models of Kawasaki disease, it is helpful to better understand the pathophysiology, cytokines and molecular pathways related to disease advancement of Kawasaki disease. At the same time, it will augment the way for the development of new and effective diagnosis and treatment of Kawasaki disease. Therefore, based on the study of coronary artery lesion animal model of Kawasaki disease with stem cells, this article mainly discusses the research and new progress of Kawasaki disease animal models, so as to provide a good theoretical basis for clinical and animal experimental research. And make a review on this issue.

Stem cells kawasaki disease coronary artery lesion animal model research progress

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