Nerium oleander Distillate Can Reduce Oxidative Deoxyribonucleic Acid Damage in Rats Fed with High Cholesterol Diet
Esma Menevse, Burak Dik, Abdullah Sivrikaya, Ahmet Levent Bas, Mutahire Tok
Annual Research & Review in Biology · pp. 1–7 · Published 22 Feb 2018
10.9734/ARRB/2018/39483Abstract
Aim: To evaluate the effect of Nerium oleander distillate on the high cholesterol diet(HCD) induced oxidative deoxyribonucleic acid damage via assessing blood 8-hydroxy-2'-deoxyguanosine(8-OHdG) and superoxide dismutase(SOD) levels. Methodolody: Twenty-one male Sprague-Dawley rats were divided equally into three groups. The first group (control group) was fed a normal diet and administered 0.5 ml distilled water via gavage for 90 days. The second and third groups were fed with HCD. The second group was administered 0.5 ml distilled water and the third group was administered 0.5 ml Nerium oleander distillate(0.375 mg/rat) via gavage for 90 days, after being fed the HCD for two weeks. Blood samples were collected, and 8-OHdG and SOD levels were measured. Results: 8-OHdG levels were statistically significantly different in all groups. Highest 8-OHdG levels were determined in the second group whereas Nerium oleander treatment reduced the level of 8-OHdG. In addition, decreased SOD levels were detected in the rats fed with HCD(Groups 2 and 3) when compared to the control group. Conclusion: It may be stated that HCD may cause oxidative damage in deoxyribonucleic acid and Nerium oleander distillate may reduce this damage. Hence, Nerium oleander distillate may show beneficial effects in the treatments of diabetes mellitus, hypercholesterolemia, and metabolic syndrome. In the future, it should investigate the effect of Nerium oleander distillate on different antioxidant pathways.
References (11)
- 1 Free radical tissue damage: protective role of antioxidant nutrients 1 [DOI]
- 2 Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents [DOI]
- 3 Hypocholesterolemic Effects of a Flavonoid-Rich Extract ofHypericum perforatumL. in Rats Fed a Cholesterol-Rich Diet [DOI]
- 4 Antioxidant Activity and Total Phenolic Content of Nerium oleander L. Grown in North of Iran.
- 5 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids [DOI]
- 6 A novel antibacterial and cardiac steroid from the roots of Nerium oleander [DOI]
- 7 Nerium oleanderDistillate Improves Fat and Glucose Metabolism in High-Fat Diet-Fed Streptozotocin-Induced Diabetic Rats [DOI]
- 8 Moringa oleifera Lam. seed extract prevents fat diet induced oxidative stress in mice and protects liver cell-nuclei from hydroxyl radical mediated damage.
- 9 Oxidative DNA damage and its chromatographic determination.
- 10 Downregulation of hepatic lipoprotein assembly in rats by fermented products of Monascus pilosus [DOI]
- 11 Effect of Nerium oleander distillate administration on serum nitric oxide level [DOI]
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