Skip to content
Research Article Open access CC BY 4.0

Hyperlipidic Diet-induced Obesity Increased Proliferative Signals- AR, ERK1/2- on Mice Prostate, Which can be Restored through Physical Training

João Vitor Pereira Leite, Daniela Cristina de Cario Calaça, Pedro Augusto Silva Nogueira, Renata Graciele Zanon, Daniele Lisboa Ribeiro

Advances in Research · pp. 79–90 · Published 31 Dec 2020

10.9734/air/2020/v21i1130272

Abstract

Aims: To evaluate the effects of hyperlipidic diet on the mouse prostate and also investigate if physical exercise is able to restore such effects. Methodology: Adult male Swiss mice were fed with a balanced (ND) or hyperlipidic diet (45% saturated fat, HD) for 16 weeks. Half were submitted to a sedentary (NDS and HDS) or exercise routine (swimming- NDE and HDE) for 8 weeks. Then, the prostate was analyzed by immunoreactions (proliferating cell nuclear antigen- PCNA, androgen receptor- AR, and estrogen receptor-ERβ), western blotting (ERK 1/2), and caspase-3 activity. Results: We found that saturated fat uptake promoted 16% weight gain, increased fat-mass and hyperglycaemia, as well as reduced testosterone levels. In addition, HD atrophied prostate secretory epithelium and stimulated cell proliferation through higher expression of AR and activation of ERK signaling. Additionally, saturated fat reduced prostatic ERβ content. Physical exercise per se promoted an anabolic effect by increasing testosterone and stimulating cell proliferation in the prostate of sedentary animals. Finally, exercise was able to restore the proliferative signals caused by the hyperlipidic diet on prostate. Conclusion: We suggest that the combination of hyperlipidic diet and sedentary lifestyle could negatively affected some prostate stimulating pathways that could trigger proliferative diseases in mice and physical exercise may be  an interesting strategy to reverse such effects.

Prostate hyperlipidic diet cell proliferation androgen receptor physical exercise.

References (15)

  1. 1 Epidemiology of Prostate Cancer [DOI]
  2. 2 Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis [DOI]
  3. 3 Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer [DOI]
  4. 4 Nutritional and Socioeconomic Factors in Relation to Prostate Cancer Mortality: a Cross-National Study [DOI]
  5. 5 The fat side of prostate cancer [DOI]
  6. 6 A low–glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans [DOI]
  7. 7 The Programming of Cardiac Hypertrophy in the Offspring by Maternal Obesity Is Associated with Hyperinsulinemia, AKT, ERK, and mTOR Activation [DOI]
  8. 8 Benign Prostatic Hyperplasia: A New Metabolic Disease of the Aging Male and Its Correlation with Sexual Dysfunctions [DOI]
  9. 9 Effect of Acute Exercise on Prostate Cancer Cell Growth [DOI]
  10. 10 Recreational physical activity and risk of prostate cancer: A prospective population‐based study in Norway (the HUNT study) [DOI]
  11. 11 Swim training suppresses tumor growth in mice [DOI]
  12. 12 High‐Fat Diet Obesity Associated With Insulin Resistance Increases Cell Proliferation, Estrogen Receptor, and PI3K Proteins in Rat Ventral Prostate [DOI]
  13. 13 Prostate hyperplasia caused by long‐term obesity is characterized by high deposition of extracellular matrix and increased content of MMP ‐9 and VEGF [DOI]
  14. 14 Prostatic stromal microenvironment and experimental diabetes. [DOI]
  15. 15 A high-fat diet fed during different periods of life impairs steroidogenesis of rat Leydig cells [DOI]

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

64

Page views

0

PDF downloads

11

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.