Skip to content
Research Article Open access CC BY 4.0

GC-MS Analysis, Thermal Characterization and Biomedical Applications of Essential Oil from Cymbopogon martinii: In vitro Approach

Vikas Jha, Kunal Gharat, Darpan Kaur, Sankalp Kasbe, Kruti Maroo, Ashish Jhangiani, Omkar Parulekar, Vrushali Dhamapurkar, Kabir Thakur, Arpita Marick, Rukayya Ansari

Advances in Research · pp. 50–69 · Published 22 Sep 2022

10.9734/air/2022/v23i5912

Abstract

Background: Plant derived metabolites have served as the foundation of sophisticated systems in traditional medicine that have existed for hundreds of years and continue to supply mankind with novel treatments. Owing to its antibacterial characteristics, Gingergrass (Cymbopogon martinii) has been utilized in aromatherapy as a skin tonic. It's also been employed in Ayurvedic medicine to treat skin conditions and nerve discomfort. It helps with neuralgia, epilepsy, and anorexia, among other central nervous system disorders. Geraniol, the main constituent of Cymbopogon martinii essential oil, has numerous biological properties, including antibacterial, antioxidant, and anti-inflammatory activities, and may constitute a new class of therapeutic medicines against pancreatic and colon malignancies. In this study, an attempt was made to explore the physiochemical and bioactive properties of Cymbopogon martinii Essential oil to understand the chemical composition and thermal stability of the oil along with its efficacy against biological agents. The hydro-distillation method was used to extract the Gingergrass (Cymbopogon martinii) Essential oil and its chemical composition as well as Thermal characteristics was determined. The essential oil's potential to scavenge free radicals was evaluated, as well as its anti-inflammatory effect was determined. The essential oil's antibacterial potential was tested against a variety of drug-resistant microorganisms, while its antimalarial efficacy was investigated against Plasmodium falciparum. In addition, the EO was tested against Hela and CHO cell lines for anticancer and cytotoxic activities, respectively. Results: The GC-MS Analysis of the essential oil characterized 10 major compounds which included different classes of alcohols, esters, ketones, monoterpenes and sesquiterpenes. Thermogravimetric and differential calorimetric analysis revealed that the oil showed a stable thermograph when exposed to constant increasing temperatures. The essential oil exhibited promising antimicrobial and antimalarial activity against the drug-resistant pathogens. Further, moderate free radical scavenging activity was observed during DPPH Assay. The essential oil also showed reliable anti-inflammatory, anticancer and cytotoxic activity. Conclusion: According to the research, Cymbopogon martinii essential oil has a number of medicinal benefits and can be used as a therapeutic agent to address a range of health issues.

Cymbopogon martini essential oil GC-MS FTIR TG-DTA DSC antimicrobial antimalarial antioxidant anti-inflammatory

References (46)

  1. 1 Biological effects of essential oils – A review [DOI]
  2. 2 Genesis and development of DPPH method of antioxidant assay [DOI]
  3. 3 Essential Oils’ Chemical Characterization and Investigation of Some Biological Activities: A Critical Review [DOI]
  4. 4 Polyphenolic phytochemicals – just antioxidants or much more? [DOI]
  5. 5 Control of Pathogenic and Spoilage Microorganisms in Fresh‐cut Fruits and Fruit Juices by Traditional and Alternative Natural Antimicrobials [DOI]
  6. 6 Major bioactivities and mechanism of action of essential oils and their components [DOI]
  7. 7 Effects of Cymbopogon nardus (L.) W. Watson essential oil on the growth and morphogenesis of Aspergillus niger [DOI]
  8. 8 Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement [DOI]
  9. 9 Extraction of Essential Oils of Rosmarinus officinalis L. by Two Different Methods: Hydrodistillation and Microwave Assisted Hydrodistillation [DOI]
  10. 10 Evaluation of the antioxidant and antiproliferative potential of bioflavors [DOI]
  11. 11 Patented antiinflammatory plant drug development from traditional medicine [DOI]
  12. 12 Comparison of Cytotoxic Activity of Anticancer Drugs against Various Human Tumor Cell Lines Using In Vitro Cell-Based Approach [DOI]
  13. 13 Cytotoxic Potential of N-hexadecanoic Acid Extracted from Kigelia pinnata Leaves [DOI]
  14. 14 Cytotoxicity evaluation of a Thai herb using tetrazolium (MTT) and sulforhodamine B (SRB) assays [DOI]
  15. 15 Biological Activities of the Essential Oil and Methanol Extract of Achillea biebersteinii Afan. (Asteraceae)
  16. 16 Comparison of radical-scavenging activities for selected phenolic acids
  17. 17 GC-MS Analysis of the Composition of the Essential Oil from Dendranthema indicum Var. Aromaticum Using Three Extraction Methods and Two Columns [DOI]
  18. 18 In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine [DOI]
  19. 19 Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guided assay using lipopolysaccharide-stimulated macrophages [DOI]
  20. 20 Antimicrobial activities and mechanism of the essential oil from Artemisia argyi Levl. et Van. var. argyi cv. Qiai [DOI]
  21. 21 Validation of a method of broth microdilution for the determination of antibacterial activity of essential oils [DOI]
  22. 22 Cymbopogon essential oils: chemical compositions and bioactivities.
  23. 23 Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice [DOI]
  24. 24 Environmental interactions with the toxicity of plant essential oils to the poultry red mite Dermanyssus gallinae [DOI]
  25. 25 Variation in the essential oil content and composition of Citronella (Cymbopogon winterianus Jowitt.) in relation to time of harvest and weather conditions [DOI]
  26. 26 Composition of Three Essential Oils, and their Mammalian Cell Toxicity and Antimycobacterial Activity against Drug Resistant-Tuberculosis and Nontuberculous Mycobacteria Strains [DOI]
  27. 27 Anti-Mycobacterium tuberculosis activity of essential oil and 6,7-dehydroroyleanone isolated from leaves of Tetradenia riparia (Hochst.) Codd (Lamiaceae) [DOI]
  28. 28 Consistent DSC and TGA Methodology as Basis for the Measurement and Comparison of Thermo-Physical Properties of Phase Change Materials [DOI]
  29. 29 A Rapid, Micro FAME Preparation Method for Vegetable Oil Fatty Acid Analysis by Gas Chromatography [DOI]
  30. 30 Chemical Composition and Antimicrobial Activity of Three Essential Oils from Curcuma wenyujin [DOI]
  31. 31 Antioxidant and Anti-inflammatory Activities of Essential Oil and Extracts of Piper miniatum [DOI]
  32. 32 Applications of Differential Scanning Calorimetry (DSC) in Oils and Fats Research. A Review [DOI]
  33. 33 Floral studies of palmarosa [Cymbopogon martinii (Roxb.) W. Watson] and chemical insights during inflorescence development [DOI]
  34. 34 Rapid Staining of Malarial Parasites by a Water Soluble Stain.
  35. 35 Antibacterial activity of essential oils from Cymbopogon: inter- and intra-specific differences.
  36. 36 Biotransformation of geranyl acetate to geraniol during palmarosa (Cymbopogon martinii, Roxb. wats. var. motia) inflorescence development [DOI]
  37. 37 Anticancer activity ofCocculus hirsutusagainst Dalton’s lymphoma ascites (DLA) cells in mice [DOI]
  38. 38 Computational Methods to Identify New Antibacterial Targets [DOI]
  39. 39 Anticancer activity of cissampelos pareira against dalton′s lymphoma ascites bearing mice [DOI]
  40. 40 Major constituents and anthelmintic activity of volatile oils from leaves and flowers ofCymbopogon martiniRoxb. [DOI]
  41. 41 Pharmacological interactions of essential oil constituents on the in vitro growth of Plasmodium falciparum [DOI]
  42. 42 Anti-biofilm property of essential oils from Cymbopogon sp. against pathogenic bacteria in single-culture and co-culture [DOI]
  43. 43 Chemical composition, antioxidant and anticancer activity of the essential oil from myric rubra leaves [DOI]
  44. 44 EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY OF CITRUS MACROPTERA MONTR [DOI]
  45. 45 Chemical composition and larvicidal activity of Elaeagnus indica Servett. (Elaeagnaceae) plant leaf extracts against dengue and malaria vectors
  46. 46 Thermogravimetric and differential thermal analysis of potassium bicarbonate contaminated cellulose

Cited by 1

Article metrics

Real usage data collected on this platform.

40

Page views

0

PDF downloads

5

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.