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Research Article Open access CC BY 4.0

Frequency of HEV Antibodies in Pregnant Women and Its Association with Existent Risk Factors, Sudan: A Cross-Sectional Study

Yousif Elnour Elsharif, Khidir Osman Alfaki, Samah Abdelrahim Elawad, Ahmed Alsiddiq Ebraheem, Mohamed Magzob, Abdelrahman Eldaw Mohammed, Elhadi Abdalla Ahmed

Microbiology Research Journal International · pp. 1–7 · Published 16 Aug 2023

10.9734/mrji/2023/v33i61385

Abstract

Background: Hepatitis E virus (HEV) infection is an increasing global problem and high endemicity is observed in many developing countries. Pregnancy predisposes women to chronic infection and various complications. Objective: This study aimed to investigate sero-positivity of HEV and existent risk factors among pregnant women in Gezira State, Sudan. Methods: A cross-sectional design was followed, and a non–probability convenience sampling technique was used to collect 120 venous blood samples from pregnant women. Separated serum specimens was used for the quantitative detection of specific anti-HEV IgM and IgG by competitive ELISA method (MIKROGEN GmbH - Germany). Results: The frequency of positive results for HEV IgG antibodies in the study population amounted to 44.2 (53/120). Of the 53 HEV IgG positive pregnant participants 47.2% (25/53) were in the third trimester period, 39.6% (21/53) had preterm labor, 39.6% (21/53) had a history of abortion and 24.5% (13/53) with jaundice. Significant association was found between HEV IgG positive women and preterm labor (p-value 0.004), and history of jaundice (p-value 0.009). Conclusion: This preliminary study highlighted the high frequency of sero-positivity of hepatitis E virus in pregnant women in the studied area of Sudan.

Hepatitis E pregnant women risk factors ELISA Sudan

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