Effects of Oral L-carnitine Supplementation on Lipid Profiles and Anemia in Patients under Hemodialysis in Gonbadkavoos, Iran
Samira Eshghinia, Abdoljalal Marjani, Behrouz Ebrahim Zadeh Kor
Annual Research & Review in Biology · pp. 1092–1098 · Published 21 Dec 2013
10.9734/ARRB/2014/7538Abstract
Aims: L-carnitine is an amino acid derivative, produced endogenously in the kidneys and liver or derived from meat and dairy products in the diet. Impaired L-carnitine synthesis by the kidneys contributes to the L-carnitine deficiency in dialysis patients. The aim of this study was to evaluate the effect of oral L-carnitine supplementation on lipid profiles and anemia in hemodialysis patients. Study Design: Thirty and four eligible patients were assigned to either L-carnitine or placebo groups based on the random. The patients in the L-carnitine group received 1 vial 1g (10 ml) of L-carnitine oral supplement 3 day a week after dialysis, for 16 weeks and the patients in the placebo group received 10 ml distilled water as in the same manner and duration. Blood sample was collected at the onset and after 16 weeks intervention for laboratory evaluations of biochemical and hematological parameters. Place and Duration of Study: Hemodialysis patients were chosen in Motahary Hospital in Gonbadkavoos, Iran, between September 2012 and March 2013. Results: The concentration of very low density lipoprotein and triglyceride were significantly decreased in L-carnitine group, whereas, none of these differences were statistically significant in placebo group whereas other measured biochemical parameters were not shown significant changes in both group. Conclusion: It seems that further experimental investigations are needed to clarify the effects of LC on lipid profiles, anemia and other factors in hemodialysis patients.
References (19)
- 1 Chronic Kidney Disease and Mortality Risk [DOI]
- 2 Effects of L-Carnitine Supplementation in Maintenance Hemodialysis Patients [DOI]
- 3 Incidence of Chronic Kidney Disease and Its Risk Factors, Results of Over 10 Year Follow Up in an Iranian Cohort [DOI]
- 4 Dyslipidemia in Chronic Kidney Disease: An Approach to Pathogenesis and Treatment [DOI]
- 5 Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine [DOI]
- 6 The effect of l-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus [DOI]
- 7 Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients [DOI]
- 8 Effects of Oral L-Carnitine Supplementation on Lipid Profile, Anemia, and Quality of Life in Chronic Renal Disease Patients under Hemodialysis: A Randomized, Double-Blinded, Placebo-Controlled Trial [DOI]
- 9 Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy.
- 10 Lipid-lowering therapy in patients with renal disease [DOI]
- 11 Effect of L-Carnitine Supplementation in Hemodialysis Patients [DOI]
- 12 Chronic Kidney Disease as a Metabolic Syndrome with Malnutrition-Need for Strict Control of Risk Factors [DOI]
- 13 HEMATOLOGY: ISSUES IN THE DIALYSIS PATIENT: Dialysis‐Related Carnitine Disorder [DOI]
- 14 Effect of L-Carnitine Supplementation on Lipid Parameters in Hemodialysis Patients [DOI]
- 15 L‐Carnitine Supplementation in Dialysis: Treatment in Quest of Disease [DOI]
- 16 Debate Forum: Levocarnitine Therapy Is Rational and Justified in Selected Dialysis Patients [DOI]
- 17 A study of atherosclerosis in patients with chronic renal failure with special reference to Carotid Artery Intima Media Thickness [DOI]
- 18 CARNITINE IMPROVES LIPID ANOMALIES IN HAEMODIALYSIS PATIENTS [DOI]
- 19 Effects of L-Carnitine Supplementation on Serum Lipids and Apoproteins in Hemodialysis Patients with Lp(a) Hyperlipoproteinemia
Cited by 9
Mehdi Karimi, Samira Pirzad, Seyed Morteza Ali Pourfaraji · Frontiers in Medicine · 2024
Sina Raissi Dehkordi, Mahsa Malekahmadi, Mahlagha Nikbaf-Shandiz · PharmaNutrition · 2023
H. Raeisi-Dehkordi, T. Muka · Clinical Nutrition · 2020
Moein Askarpour, A. Hadi, M. Symonds · NMCD. Nutrition Metabolism and Cardiovascular Diseases · 2019
Showing 4 of 9 known citations — external sources report more than can currently be individually listed.
Related research
- Prognostic Value of NT-proBNP Concentrations in Patients Attending a Hospital Cardiac Service — shares topic coverage
- Assessment of Obstetric Characteristics Associate with Anemia Disease among Pregnant Women Attending Antenatal Clinics at Garowe General Hospital, Somalia — shares topic coverage
- Relationship between Food and Iron Intake and Hemoglobin Levels among Medical Students: A Cross-sectional Study at Indonesian Christian University, Class of 2021 — shares topic coverage
- The Correlation between Anti GAD65 Antibody and Autoimmune Encephalitis with Seizures Responding to IVIG and Rituximab: A Case Report — shares topic coverage
- Understanding Anemia of Odisha: Evidence from National Family Health Surveys — shares topic coverage
Article metrics
Real usage data collected on this platform.
59
Page views
0
PDF downloads
31
Outbound clicks
9
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.