Skip to content
Research Article Open access CC BY 4.0

Comparison of Serum IgE Level between Initial Attack and Relapse Cases of Idiopathic Nephrotic Syndrome in Children

Mohammad Naim Iqbal Mollah, Md. Abdur Rouf, Mohammad Moniruzzaman Bhuiyan, Mohammad Sazzad Hossain Chowdhury, Azreen Chowdhury, Bilkis Sultana

Asian Journal of Pediatric Research · pp. 116–124 · Published 29 Nov 2023

10.9734/ajpr/2023/v13i4299

Abstract

Background: Nephrotic Syndrome (NS) is a common and recurrent glomerular disease in childhood. Although the exact etiology of NS is not fully known, it is believed that immune system plays a pivotal role in its pathogenesis. Studies have been reported a strong association between NS and increased level of serum immunoglobulin E (IgE). In addition, children with recurrent NS, the IgE level significantly increases, and there is a higher relapse rate. Objective: The aim of the study was to determine the difference of Serum IgE level between initial attack and relapse cases of idiopathic Nephrotic Syndrome in children. Methodology: A cross sectional analytical study has been conducted on 35 initial attack and 35 relapse cases of idiopathic Nephrotic Syndrome children admitted in the Department of paediatrics, Sir Salimullah Medical College Mitford Hospital (SSMCMH), Dhaka from May 2021 to April 2022. Study subjects were enrolled by purposive sampling after confirming the diagnosis and fulfilling the inclusion and exclusion criteria. Informed written consent was taken from each patient's legal guardian before enrollment. A detailed history and thorough physical examination was done in each patient on admission. With all aseptic precaution five ml of venous blood was collected and sent for serum albumin, serum cholesterol and serum IgE level measurement. Data were analyzed using the statistical package for social sciences (SPSS) version 23.0. Independent sample t test or Mann-whitney test was used to compare data between groups. P value of less than 0.05 was considered as significant. Results: The mean age of the studied samples was 3.86 (ranging from 2 to 6 years). Moreover, among the studied sample male was a little bit greater than female. A significant prevalence of relapse cases were found among the children with middle income family status (P<0.05).Spot urine protein and creatinine ratio and serum cholesterol level was significantly higher in patients experience relapse attack (P<0.05). However, serum albumin level was quite similar in both cases. The mean serum IgE of patients experiencing relapse attack was 985.11+433.65 which was significantly higher than patients experiencing initial attack 470.48+227.35 (P<0.001).  Conclusion: This study showed that serum IgE levels are higher in relapse cases of Nephrotic Syndrome than that of initial attack. Furthermore, serum IgE is more in frequent relapse as compared to infrequent relapse. Serum IgE levels have a positive correlation with disease activity and relapse of Nephrotic Syndrome.

Idiopathic nephrotic syndrome initial attack relapse serum immunoglobulin E (IgE)

References (31)

  1. 1 Nelson textbook of pediatrics [DOI]
  2. 2 Nephrotic syndrome in childhood [DOI]
  3. 3 Idiopathic nephrotic syndrome in children [DOI]
  4. 4 Greenhouse gas emissions from home composting of organic household waste [DOI]
  5. 5 Ethnic Differences in Childhood Nephrotic Syndrome [DOI]
  6. 6 Management of steroid sensitive nephrotic syndrome: revised guidelines.
  7. 7 Incidence and Relapse of Idiopathic Nephrotic Syndrome: Meta-analysis [DOI]
  8. 8 Nephrotic Syndrome in Children [DOI]
  9. 9 Steroid-responsive nephrotic syndrome and allergy: immunological studies. [DOI]
  10. 10 Occurrence of Common Allergic Diseases in Children with Idiopathic Nephrotic Syndrome [DOI]
  11. 11 Risk Factor for Relapse in Childhood Nephrotic Syndrome - A Hospital Based Retrospective Study [DOI]
  12. 12 A Study of the Relationship between Childhood Nephrotic Syndrome and Allergic Diseases [DOI]
  13. 13 Risk factors for relapse in childhood nephrotic syndrome [DOI]
  14. 14 Serum Immunoglobulin E and Interleukin-13 Levels in Children with Idiopathic Nephrotic Syndrome [DOI]
  15. 15 Involvement of 5-HT2 receptors in the wet-dog shake behaviour induced by 5-hydroxytryptophan in the rat [DOI]
  16. 16 Serum IgE in Primary Glomerular Diseases and Its Clinical Significance [DOI]
  17. 17 Nephrotic Syndrome in Childhood [DOI]
  18. 18 Implication of serum IgE in childhood nephrotic syndrome [DOI]
  19. 19 Steroid sensitive nephrotic syndrome [DOI]
  20. 20 Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children - Short Review.
  21. 21 Study of risk factors for relapse in frequently versus infrequently relapsing nephrotic syndrome in 1-18 year age group: a combined prospective retrospective cohort analytical observational study [DOI]
  22. 22 Serum Immunoglobulin E in Idiopathic Nephrotic Syndrome [DOI]
  23. 23 Relationship between serum IgE and frequent relapse idiopathic nephrotic syndrome.
  24. 24 Steroid resistant nephrotic syndrome [DOI]
  25. 25 Serum IgE level in relapsing idiopathic nephrotic syndrome in children [DOI]
  26. 26 Risk factors for relapse in pediatric nephrotic syndrome [DOI]
  27. 27 Prognostic Value of Biochemical and Hematological Parameters in Children with Nephrotic Syndrome [DOI]
  28. 28 Angiotensin converting enzyme gene polymorphism in Indian children with steroid sensitive nephrotic syndrome [DOI]
  29. 29 Immune status of children suffering from minimal change nephrotic syndrome.
  30. 30 808 A study of the relationship between childhood nephrotic syndrome and allergic diseases [DOI]
  31. 31 Clinical Review of Idiopathic Nephrotic Syndrome in Children.

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

13

Page views

0

PDF downloads

1

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.