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Research Article Open access CC BY 4.0

Bio-chemical Preparation of Microcrystalline Cellulose Powder from Cotton Linters for Utilization as Tablet Excipients

Harshali N. Shende, Varsha Satankar, Vellaichamy Mageshwaran

Microbiology Research Journal International · pp. 11–19 · Published 22 May 2024

10.9734/mrji/2024/v34i61448

Abstract

Aims: The present work is aimed to prepare microcrystalline cellulose (MCC) powder from cotton linters by an eco-friendly bio-chemical process and to evaluate the prepared MCC as tablet excipients. Study Design: Randomized Complete Block Design. Place and Duration of Study: Ginning Training Center, ICAR-Central Institute for Research on Cotton Technology, Nagpur, Maharashtra, India during June to December, 2019. Methodology: The MCC was prepared from cotton linters by enzymatic and chemical methods and compared with commercial grade MCC (Avicel® PH101). The crude enzyme extract of Aspergillus sp. VM-1 was obtained by solid-state fermentation and used for hydrolysis of cotton linters at 60℃ for 60 min. In the chemical process, 10% alkali was used for hydrolysis at boiling temperature for 60 min. In both the processes, the hydrolyzed cotton linters were bleached with hydrogen peroxide. The MCC powders were characterized for physico-chemical and tableting properties based on Indian Pharmacopeia (IP) and Untied States Pharmacopeia (USP) specifications. Results: The α-cellulose content (%) in the synthesized MCC by enzymatic process was 98.1 while the commercial grade MCC, Avicel® PH101 had 98.5. The physico-chemical properties of synthesized MCC by enzymatic process were comparable with Avicel PH101 and meet the IP standards. The degree of polymerization (DP) of prepared MCC and Avicel PH101 were 215 and 157, respectively. The FT-IR spectrum of synthesized MCC had similarity to that of Avicel® PH101. The tableting properties of prepared MCC met USP standards. The MCC prepared from cotton linters by enzymatic was found to be superior to chemical process with respect to cellulose yield, degree of polymerization and tablet dissolution property. Conclusion: The results showed MCC synthesized from cotton linters through enzymatic route is a promising candidate for direct compressible excipient of tablet. The present study highlights that the enzymatic process significantly reduces the alkali usage and heating temperature and thus saves the chemicals and energy in the process. 

Aspergillus sp. bio-chemical cotton linters chemical process crude enzyme enzymatic process microcrystalline cellulose tablet excipient

References (18)

  1. 1 Wood and Cellulose Science
  2. 2 Mechanism of moisture induced variations in true density and compaction properties of microcrystalline cellulose [DOI]
  3. 3 Physicochemical, spectroscopic and thermal properties of microcrystalline cellulose derived from corn cobs [DOI]
  4. 4 Extraction of natural cellulosic fibers from cornhusk and its physico-chemical properties [DOI]
  5. 5 Direct Compression and the Role of Filler-binders [DOI]
  6. 6 Comparative compaction properties of various Microcrystalline Cellulose types and Generic Products [DOI]
  7. 7 Coupled acid and enzyme mediated production of microcrystalline cellulose from corn cob and cotton gin waste [DOI]
  8. 8 Compaction Properties of Microcrystalline Cellulose Using Tableting Indices [DOI]
  9. 9 Obtaining microcrystalline cellulose from softwood and hardwood pulp [DOI]
  10. 10 Preparation of Microcrystalline Cellulose from Cotton and its Evaluation as Direct Compressible Excipient in the Formulation of Naproxen Tablets [DOI]
  11. 11 Preparation and Properties of Microcrystalline Cellulose from Corn Residues [DOI]
  12. 12 Microcrystalline cellulose powder from banana pseudostem fibres using bio-chemical route
  13. 13 The Harvesting and Ginning of Cotton [DOI]
  14. 14 Bio-scouring of Non-spinnable Cotton by a Crude Enzyme of a New Fungal Strain Aspergillus sp. VM-1, Isolated from Banana Pseudostem Waste [DOI]
  15. 15 Structure-function Relationships of Highly Refined Cellulose Made from Agricultural Fibrous Residues [DOI]
  16. 16 Optimization of Micro Crystalline Cellulose Production from Corn Cob for Pharmaceutical Industry Investment
  17. 17 Optimization of enzymatic process for preparation of absorbent cotton
  18. 18 Eco-Friendly Process of Absorbent Cotton Preparation for Rural Entrepreneurship [DOI]

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