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Research Article Open access CC BY 4.0

Beta-Lactam Resistance and Phenotypic Detection of Extended-Spectrum Beta-Lactamase in Entero bacteriaceae Isolated from Community-Acquired Urinary Tract Infections

Kasamba Ilunga Éric, Hichika Tshikolasoni Papy

South Asian Journal of Research in Microbiology · pp. 15–24 · Published 6 Feb 2024

10.9734/sajrm/2024/v18i2345

Abstract

Introduction: Urinary tract infections can affect all individuals, regardless of gender and age, occupying a prominent place in nephrological pathology. The biggest problem is that a pathology with a wide range of antibiotics and other hygiene measures that can remedy it, remains so frequent with sometimes serious complications that can compromise the vital prognosis. Objectives: To determine antibiogram profile of enterobacteria in urinary infections. Methodology: This is a cross-sectional study with an analytical aim of enterobacteria isolated from urinary infections from samples from patients of all ages from January 1, 2020 to October 21, 2022. Results: the isolated enterobacteria strains presented high rates of resistance, i.e. 92.61% for Ampicillin, 47.94% for cefadroxil, 45.14% for cefuroxime and 46.46% for cefotaxime, 72.86% for amoxicillin and 40.44% for amoxicillin + clavulanic acid. Qualitative detection of extended spectrum Beta Lactamase was generally evaluated at 24.8% with peaks for Citrobacter sp, Klebsiella sp and E coli. For the latter, cross-resistance to quinolones was evaluated in proportions ranging from 49.45% to 85.51%. Conclusion: This study shows that the level of resistance of enterobacteria to beta-lactams is very high. We have observed co-resistance between beta-lactams and quinolones, antibiotics commonly used against Gram-Negative bacteria. This observation requires an improvement in the antibiotic management policy.

Infection antibiotic beta-lactam phenotypic

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Mujahid, H., Ibrahim, D., Bashir, I. · UMYU Journal of Microbiology Research (UJMR) · 2024

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