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Research Article Open access CC BY 4.0

Antibiotic Resistance Pattern of Staphylococcus aureus and Associated Risk Factors in the Adamaoua and Far North Regions of Cameroon

Mansour Mohamadou, Sarah Riwom Essama, Lilian Akwah, Aline Bamia, Elie Velhima Adamou, Marie Chantal Ngonde, Calixte Mbakop, Damdam Fadimatou Bello, Jacob Ndoumwe, Paul Djidere Yafowo, Rosine Njapndounke, Hortense Gonsu Kamga

Microbiology Research Journal International · pp. 1–11 · Published 31 Dec 2020

10.9734/mrji/2020/v30i1130278

Abstract

Background: Infections due to Staphylococcus aureus (S. aureus) have been recognized as an important public health problem worldwide. Resistant S. aureus strains emerged and its prevalence has been on the rise. Many risk factors were identified as comorbidities and impact seriously the health state of infected individual by resistant Staphylococcus aureus. We focus our study on two of these risk factors (HIV-infection and diabetes) which may constitute high potential health conditions for emergence of resistant S. aureus strains.    Methods: A Cross sectional study was conducted during 19 months in five laboratories in the northern Cameroon. Collection of clinical samples from nine different types of specimens and first identifications were conducted in the various sites of study. Selected strains were transported in Yaoundé using standard procedure. Identification and drug susceptibility testing was performed using the disk diffusion method. Questionnaires were submitted to all the participants after an approved written and oral consent. HIV and Glycemia test were carried out on each patient in case their status was not known. During the study, 380 strains of Staphylococcus aureus were identified. Antimicrobial test was achieved using 16 different antibiotics. Results: Result showed that 202/380 (53.2 %) of Staphylococcus aureus were resistant to at least three antibiotics (multiresistant) from three different families. Multiresistant strains displayed high resistance to cotrimoxal (76.7 %) followed by penicillin (66.8 %), tetracyclin (57.4 %) and oxacillin (51.5%). While high rate of sensitivity were obtained for rifampicin (78.7 %), fusidic acid (65.8 %), lincomycin (60.5 %) and minocyclin (58.9 %). Few participants 8.9 % were tested HIV positive and 7.9% were living with diabetes. Strains isolated from participants living with these diseases presented higher rate of resistance to antibiotics. Conclusion: The rate of multiresistant Staphylococcus aureus are constantly in progress in northern Cameroon, most of the strains originated from community. These strains exhibited high resistance level to cotrimoxazol while displaying high sensitivity to rifampicine. People living with chronic diseases presented high resistance to antibiotic recommended for S. aureus infection treatment.

Antibiotic resistance Staphylococcus aureus community acquired S. aureus hospital acquired S. aureus.

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Cited by 2

Methicillin-Resistant Staphylococcus aureus (MRSA): A major concern in the Northern Cameroon

B. Gaké, Aline Bamia, Mansour Mohamadou · GSC Biological and Pharmaceutical Sciences · 2022

Prevalence and Antimicrobial Resistance Pattern of Community Acquired Staphylococcus aureus in Patients Received at the Traumatology Unit of a Secondary Referral Health Setting in the Western Cameroon

Viany Nankeng Manhafo, T. D. Tadongfack, Irina Lydia Sudeu Nitcheu · International Journal of Pathogen Research · 2021

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