Paul Chinwuba, Chimaobi O. Ugorji, Daniel L. Ajaghaku, Winifred O. Amattah, Amara A. Ajaghaku, Onyesife C. Obiageli, Zogini U. Confidence, Victor T. Ezeifeh & Okoro O. Kingsley·Journal of Pharmaceutical Research International·2025
Neuroinflammation driven by the NLRP3 inflammasome is a key mechanism in many neurological disorders. While plant-derived polyphenols and terpenoids individually show anti-inflammatory potential, their synergistic effects remain underexplored. This review highlights the enhanced...
Open access
Research Article10.9734/jpri/2025/v37i117762
In postmenopausal women, a substantial decrease in circulating estrogen levels has been strongly associated with an increased risk of cognitive dysfunction. Both clinical and preclinical studies have demonstrated that estrogen positively affects synaptic plasticity, hippocampal n...
Open access
Research Article10.9734/ajrimps/2025/v14i3340
Plant-drug interactions mediated by cytochrome P450 (CYP450) enzymes are a critical area of study owing to their potential to alter drug metabolism, efficacy, and toxicity. This review examines how common phytochemicals such as flavonoids, polyphenols, alkaloids, and terpenes mod...
Open access
Research Article10.9734/jamps/2025/v27i8808
Momordica charantia (bitter melon) is a tropical vine with a long history in traditional medicine. Recent studies have focused on its therapeutic applications, particularly for diabetes, metabolic syndrome, and polycystic ovary syndrome (PCOS). The plant contains bioactive compou...
Open access
Research Article10.9734/jocamr/2025/v26i8688
Daniel Lotanna Ajaghaku, Chibueze Peter Ihekwereme & Paul Chinwuba·Asian Journal of Biology·2025
This study investigated the effects of supplementation with a phenol-rich fraction of Musanga cecropioides (PRF-MC) on malaria and primaquine (PQ)-induced oxidative stress inSwiss albino mice. Plasmodium berghei infected mice were treated with PQ alone (0.25 mg/kg) and in combina...
Open access
Research Article10.9734/ajob/2025/v21i8544