Oluwaseun Samuel Hezekiah

Sequential Administration of Febuxostat, Amlodipine and Vitamin E Attenuate Oxidative Stress and Improve Spermatogenesis in Testicular Ischemia Reperfusion Injury in Wistar Rats

Richard Adedamola Ajike, Oladele Ayobami Afolabi, Ayodeji Folorunsho Ajayi, Olajumoke Deborah Ogunleye, Waidi Adeoye Saka, Olusola Bamidele & Oluwaseun Samuel Hezekiah · International Journal of Biochemistry Research & Review · 2024

This study investigated the effects of sequential administration of febuxostat, amlodipine, and vitamin E on oxidative stress and spermatogenesis following testicular ischemia-reperfusion injury (TIRI) in Wistar rats. Ninety male rats (120-150 g) were divided into 9 groups (n=10...

Open access Research Article 10.9734/ijbcrr/2024/v33i6894

Timed Administration of Febuxostat Improved Testicular Function Following Testicular Ischemia-reperfusion Injury Via Inhibition of MDA/NO Pathway, Down-regulation of Toll-like Receptor 4 Expression and Restoration of Reproductive Hormones

Oreoluwa Janet Adedeji, Oladele Ayobami Afolabi, Richard Adedamola Ajike, Olubunmi Simeone Oyekunle, Waidi Adeoye Saka, Olajumoke Deborah Ogunleye, Bamidele Oluwole Olusola, Oluwaseun Samuel Hezekiah, Sodiq Opeyemi Hammed & Babatunde Adebola Alabi · Journal of Advances in Biology & Biotechnology · 2024

Introduction: Testicular ischemia-reperfusion injury (TIRI) generates reactive oxygen species (ROS) through xanthine oxidase (XO) activity in the ischemic phase and leukocyte infiltration to the site of injury during reperfusion leading to oxidative stress, inflammation, and disr...

Open access Research Article 10.9734/jabb/2024/v27i121800