Over the past three decades, TGM2, a stress-responsive gene encoding transglutaminase 2 (TG2) has been identified as one of the several genes that may be involved in carcinogenesis and cancer physiology. TG2 is a pleiotropic calcium-dependent enzyme belonging to the transglutamin...
Open access
Research Article10.9734/BJMMR/2015/13919
Transglutaminase 2 (TG2) belongs to the family of transglutaminase, a large group of intracellular and extracellular enzymes that primarily catalyze the Ca2+-dependent post-translational modification of proteins. Discovery of the first transglutaminase in the early 1920s, has sub...
Open access
Research Article10.9734/IJBCRR/2014/6363
Focus on cancer therapy is experiencing a major paradigm shift from ways of attacking tumor cells to a strategy for specifically targeting the tumor microenvironment (TME). This approach requires a comprehensive understanding of roles of each component of the tumor environment. A...
Open access
Research Article10.9734/BJMMR/2013/2866
It is now generally accepted that prostate cancer is the leading form of cancer in men. Current evidence indicates that countries including America and West Africa have more cases of aggressive progressive prostate cancer. Many treatment strategies have been used in management of...
Open access
Research Article10.9734/BJMMR/2013/2637