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Mandakini Mandale

Publications (19)

Orthokeratinized Odontogenic Cyst: A Case Series with Clinicopathologic Variation

Mandakini Mandale, Vaishnavi Marge, Jayanti Humbe, Vaishali Nandkhedkar, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

Orthokeratinized Odontogenic Cyst (OOC) is a rare developmental odontogenic cyst, accounting for approximately 1% of all odontogenic cysts and 10% of all keratinizing odontogenic jaw cysts. The 2017 WHO classification considered OOC as a distinct entity. It is characterized by an...

Open access Research Article 10.9734/ijrrd/2025/v8i2231

Benign Yet Complex: Pleomorphic Adenoma of the Hard Palate

Mandakini Mandale, Siddhi Kothari, Jayanti Humbe, Vaishali Nandkhedkar, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

Pleomorphic Adenoma is the most common tumor affecting both major and minor salivary glands and the most common intraoral site is the palate. 23 A male complained of a hard, painless mass over the left side of the hard palate, persisting for the last 2 years. On examination, a fi...

Open access Research Article 10.9734/ijrrd/2025/v8i1213

Calretinin: An Explicit Marker for Ameloblastoma

Mandakini Mandale, Anushree Patil, Jayanti Humbe, Vaishali Nandkhedkar & Savita Wagh · International Journal of Research and Reports in Dentistry · 2024

We report 3 cases of dentigerous cyst showing ameloblastomatous changes, radicular cyst revealing ameloblastoma like features and Basal cell adenoma mimicking ameloblastoma. A wide range of diseases known as odontogenic cysts and tumors develop from the tooth-forming mechanism an...

Open access Research Article

Renal Cell Carcinoma with Metastases to Oral Cavity: A Systematic Review

Vaishnavi Marge, Mandakini Mandale, Jayanti Humbe, Vaishali Nandkhedkar & Savita Wagh · Asian Oncology Research Journal · 2026

Introduction: Metastasis of renal cell carcinoma (RCC) to the oral cavity is uncommon but clinically significant and often presents with non-specific features resembling benign or reactive oral lesions. In some patients, the oral lesion may be the first clinical manifestation of...

Open access Research Article 10.9734/aorj/2026/v9i1142

Prevalence of Oral Squamous Cell Carcinoma Among Young Patients: A Retrospective Study

Vaishali Nandkhedkar, Mandakini Mandale, Jayanti Humbe, Savita Wagh, Monika Kajalkar & Shubhankar Nandkhedkar · International Journal of Research and Reports in Dentistry · 2025

Background: Oral squamous cell carcinoma (OSCC) ranks as the 12th most common cancer globally, with an increasing prevalence among young adults. Traditionally associated with older populations, recent evidence suggests a worrying rise in early-onset cases, particularly in economi...

Open access Research Article 10.9734/ijrrd/2025/v8i2233

Oral and Cutaneous Involvement in Langerhans Cell Histiocytosis: A Systematic Review

Siddhi Kothari, Mandakini Mandale, Jayanti Humbe, Vaishali Nandkhedkar, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

Background: Langerhans Cell Histiocytosis (LCH) is a rare disorder characterised by clonal proliferation of Langerhans cells, with potential involvement of multiple organ systems, including the skin and oral cavity. Oral and cutaneous lesions may represent early signs of systemic...

Open access Research Article 10.9734/ijrrd/2025/v8i2227

Lymphoepithelial Carcinoma of Oral Cavity: A Systematic Review

Kanika Dang, Mandakini Mandale, Jayanti Humbe, Vaishali Nandkhedkar, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

Introduction: Lymphoepithelial Carcinoma is a subtype of Oral Squamous Cell Carcinoma, morphologically similar to non-keratinizing Nasopharyngeal Carcinoma, un-differentiated subtype. Oral Lymphoepithelial Carcinoma is extremely rare and its characteristics differs from those at...

Open access Research Article 10.9734/ijrrd/2025/v8i2224

Odontogenic Keratocyst or Mimickers: Highlighting the Importance of Excisional Biopsy

Jayanti Humbe, Mandakini Mandale, Vaishali Nandkhedkar, Savita Wagh & Aarti More · International Journal of Research and Reports in Dentistry · 2025

Odontogenic keratocyst (OKC) is a odontogenic cyst characterized by its aggressive behavior and high recurrence rate. OKC typically presents as a unilocular lesion, however bilateral or multiple OKCs can be present. Usually they are often associated with bifid-rib basal cell nevu...

Open access Research Article 10.9734/ijrrd/2025/v8i1212

Clinico- Pathological Features of Spindle Cell Carcinoma of the Oral Cavity: A Systematic Review

Akanksha Bhardwaj, Mandakini Mandale, Jayanti Humbe, Vaishali Nandkhedkar & Savita Wagh · International Journal of Research and Reports in Dentistry · 2024

Introduction: Oral Spindle Cell Carcinoma (OSCC) is a rare and aggressive form of oral squamous cell carcinoma (OSCC) that is characterized by the presence of spindle-shaped wcells within the tumor. It is often difficult to diagnose due to its histological similarity with other s...

Open access Research Article 10.9734/ijrrd/2024/v7i2200

Hyalinizing Clear Cell Carcinoma of Palate: A Systematic Review

Ayushi Goyal, Jayanti G. Humbe, Mandakini Mandale, Vaishali Nandkhedkar & Savita Wagh · Asian Oncology Research Journal · 2026

Hyalinising clear cell carcinoma (HCCC) is a rare, low-grade malignant tumour of minor salivary gland origin that most commonly affects the palate. This systematic review analysed the demographic profile, clinical presentation, diagnostic features, management, and outcomes of rep...

Open access Research Article 10.9734/aorj/2026/v9i1145

Histopathological Correlation of Clinically Diagnosed Radicular Cysts: A Retrospective Observational Study

Ayushi Goyal, Jayanti G. Humbe, Mandakini Mandale, Vaishali Nandkhedkar & Savita Wagh · International Journal of Research and Reports in Dentistry · 2026

Background: Radicular cysts are the most common inflammatory odontogenic cysts and are frequently diagnosed from clinical and radiographic findings. However, other odontogenic lesions can present as similar periapical radiolucencies, creating potential diagnostic discrepancies. A...

Open access Research Article 10.9734/ijrrd/2026/v9i2328

Estimation of Salivary LDH Level in Oral Lichen Planus and OSCC- A Biochemical Study

Aishwarya Karhale, Vaishali Nandkhedkar, Mandakini Mandale, Jayanti G. Humbe & Savita Wagh · International Journal of Research and Reports in Dentistry · 2026

Introduction: LDH is a cytoplasmic enzyme that appears extracellularly during cell necrosis and tissue damage. Increased LDH levels in saliva have been associated with oral diseases, including oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Normally, LDH convert...

Open access Research Article 10.9734/ijrrd/2026/v9i2322

Awareness and Perception of Artificial Intelligence Applications in Forensic Odontology: A Questionnaire-Based Cross-Sectional Study

Ayushi Goyal, Jayanti G. Humbe, Mandakini Mandale, Vaishali Nandkhedkar & Savita Wagh · International Journal of Research and Reports in Dentistry · 2026

Background: Artificial intelligence (AI) is increasingly influencing diagnostic and analytical practices in dentistry and forensic sciences. In forensic odontology, AI has been explored as an adjunctive tool for human identification, age estimation, bite mark analysis and dental...

Open access Research Article 10.9734/ijrrd/2026/v9i2314

Histopathological Evaluation of Systemic Immune-Inflammation Index (SII) in Oral Squamous Cell Carcinoma

Aishwarya Karhale, Vaishali Nandkhedkar, Mandakini Mandale, Jayanti G. Humbe & Savita Wagh · International Journal of Research and Reports in Dentistry · 2026

Introduction: Oral squamous cell carcinoma (OSCC) shows considerable biological heterogeneity in clinical behaviour and prognosis. Conventional histopathological grading remains important but may not fully reflect tumour aggressiveness or the systemic immune-inflammatory status o...

Open access Research Article 10.9734/ijrrd/2026/v9i2312

Ectodermal Dysplasia through the Lens of Clinical Cases: A Case Series

Monika Kajalkar, Jayanti Humbe, Mandakini Mandale, Vaishali Nandkhedkar & Savita Wagh · International Journal of Research and Reports in Dentistry · 2025

Ectodermal dysplasias (EDs) are a heterogeneous group of hereditary conditions marked by abnormalities in ectodermal derivatives such as teeth, hair, nails, and sweat glands. These disorders show vast phenotypic diversity and are often classified by genetic mutation or by the str...

Open access Research Article 10.9734/ijrrd/2025/v8i2243

A Rare Case Report on Ameloblastic Fibro-Odontoma

Vaishali Nandkhedkar, Aishwarya Karhale, Mandakini Mandale, Jayanti Humbe, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor composed of both epithelial and mesenchymal components, along with enamel and dentin formation. It commonly affects children and adolescents, often presenting as a slow-growing asymptomatic lesion associat...

Open access Research Article 10.9734/ijrrd/2025/v8i2242

Cementoblastoma -A Rare Case Report

Jayanti Humbe, Ayushi Goyal, Mandakini Mandale, Vaishali Nandkhedkar, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

According to the World Health Organisation, benign cementoblastoma is classified under the group of cementoma. Cementoblastoma account for up to 3% of all odontogenic tumours. This case highlights the clinical, radiographic, and histopathological features of cementoblastoma, emph...

Open access Research Article 10.9734/ijrrd/2025/v8i2235

Oral Sebaceous Carcinoma: A Systematic Review

Aarti More, Jayanti Humbe, Mandakini Mandale, Vaishali Nandkhedkar, Savita Wagh & Monika Kajalkar · International Journal of Research and Reports in Dentistry · 2025

Introduction: Sebaceous carcinoma is predominantly known as a cutaneous malignancy, most commonly arising in the periocular region. It is locally aggressive and carries a risk of metastasis. Its occurrence in the oral cavity is exceptionally rare, making it a diagnostic challenge...

Open access Research Article 10.9734/ijrrd/2025/v8i2223

Sclerosing Polycystic Adenosis of Minor Salivary Glands: A Systematic Review

Chandrakala Dhone, Jayanti Humbe, Mandakini Mandale, Vaishali Nandkhedkar & Savita Wagh · International Journal of Research and Reports in Dentistry · 2025

Introduction: Sclerosing polycystic adenosis (SPA) is a rare salivary gland condition resembling sclerosing adenosis of the breast, with both reactive and neoplastic characteristics. It has been reported in over 60 cases globally, primarily affecting major salivary glands, with f...

Open access Research Article 10.9734/ijrrd/2025/v8i1207