Efficacy and Safety of Biologics in Primary Biliary Cholangitis: A Systematic Review of Experimental Treatments
Tobechukwu Chinenye Ezike, Tania M. Cobena Bravo, Roshan Goswami, Luis Fernando Jimenez Cepeda, Huma Irfan, Tagbo Ejike Onyemelukwe, Maryfortune Ugoeze Chilaka, Ibiai Stephanie Lolomari, Vimla Devi, Sefiyah Lawal, Chukwuma Chuma-Eze, Oluwatobi Bamikole Opeyemi, Shwetha Gopal, Agho Osamede & Peace Divine Akhimienmhona · Journal of Advances in Medicine and Medical Research · 2025
Background: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive bile duct destruction, leading to liver failure if untreated. While ursodeoxycholic acid (UDCA) is the first-line therapy for PBC, 30-40% of patients exhibit an incomp...