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Karl Kingsley

Publications (19)

Screening for Oral High-risk Human Papillomavirus (HPV) among a Pediatric Patient Population

Douglas Bowen & Karl Kingsley · Journal of Advances in Medicine and Medical Research · 2019

Introduction: Human papillomavirus (HPV) is a known cancer-causing virus that has been primarily linked to cervical cancers. Recent studies have shown that HPV may also induce cancer in other tissues, including oral epithelia and mucosa. To determine the presence of oral HPV infe...

Open access Research Article 10.9734/jammr/2019/v29i930124

Prevalence of Selenomonas noxia among Pediatric and Adult Orthodontic Patients

Nimrat Dhillon, Karl Kingsley & Katherine M. Howard · International Journal of Research and Reports in Dentistry · 2019

Pediatric patients face many challenges to oral and periodontal health, including the placement of fixed orthodontic appliances during adolescence. One of the more recently identified periodontal pathogens is the organism Selenomonas noxia or S. noxia. Objectives: Due to the pauc...

Open access Research Article

Effect of Dental Sealants on Oral Microbial Burden of Scardovia wiggsiae within a Pediatric Population: A Pilot Study

Kevin Quan & Karl Kingsley · Microbiology Research Journal International · 2018

Aim: Dental caries is among the most prevalence and pervasive of childhood infections, with prevention factors such as fluoride and dental sealants regarded as the most effective prevention and treatment modalities. Many studies of dental sealants have focused on traditional cari...

Open access Research Article 10.9734/MRJI/2018/42947

Dietary Habits and Anthropometric Measures of a Dental Student Population

Ah Reum Yoo, Philip Hyunbae Son, Karl Kingsley & Joshua M. Polanski · European Journal of Nutrition & Food Safety · 2021

Introduction: Health professionals are expected to understand the relationship between diet and nutrition and overall health. Many relationships between oral health and diet and nutrition are known to contribute to health or disease development. However, few studies to date have...

Open access Research Article 10.9734/ejnfs/2021/v13i230379

HPV-16 and HPV-18 Affects Viability and Proliferation in Normal Breast Tissue Cells

Marie Louisa Heske, Teryn Mendenhall & Karl Kingsley · International Research Journal of Oncology · 2019

Introduction and Aims: Recently HPV-16 and 18 have been found in the oral cavity and have been significantly linked as causative agents of oral cancer.  Research has also shown the effects of HPV on breast cancer cells.  More recently, HPV-16 and 18 have been found in normal brea...

Open access Research Article

Assessment of Dental Pulp Stem Cell (DPSC) Biomarkers Following Induction with Bone Morphogenic Protein 2 (BMP-2)

Joseph Cinelli, Erica Nguyen & Karl Kingsley · Journal of Advances in Biology & Biotechnology · 2018

Introduction: Tissue regeneration and biomedical engineering are the goals of modern research that have made tremendous strides in recent years. Dental pulp stem cells (DPSCs) have been demonstrated to exhibit functional multipotency, differentiating into neurons, adipocytes, and...

Open access Research Article 10.9734/JABB/2018/44215

Alterations in Oral Cancer Gene Expression in Response to Melatonin

Arin Hartounian, Guillermo Alessandro Retis, Karl Kingsley & Katherine Howard · Journal of Complementary and Alternative Medical Research · 2018

Aims: Melatonin (MLT) exerts oncostatic effects on numerous tumour types presumably by inhibiting cell proliferation and promoting apoptosis. The primary aim of this study was to investigate melatonin-induced changes in gene expression patterns in two different oral squamous carc...

Open access Research Article 10.9734/JOCAMR/2018/44008

Prevalence of Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum among Clinical Orthodontic and Non-Orthodontic Saliva Samples

Jason Klingler, Ching Shen & Karl Kingsley · Journal of Advances in Microbiology · 2018

Objectives: The oral flora is a complex ecosystem characterized by numerous bacterial species and changes to the levels of these bacteria in health, disease, and dental treatments such as orthodontics. Although some studies have documented changes in periodontal pathogen burden d...

Open access Research Article 10.9734/JAMB/2018/42698

Evaluation of Differential Oral Cell-specific Responses to the E-cigarette Component Nicotine

Ian Pearson, James Luke Taylor & Karl Kingsley · International Journal of Research and Reports in Dentistry · 2018

Objectives: The recent introduction of electronic cigarettes (EC) or e-cigarettes, also known as the electronic nicotine delivery device (ENDD), has been promoted as a safer alternative to tobacco products and smoking. Many groups have advocated for the use of ECs or ENDDs as a t...

Open access Research Article

Analysis and Evaluation of the Effects of Melatonin on Oral Keratinocytes: A Pilot Study

Megan Tufteland, Allison Jae Lenon, Spencer Carlile & Karl Kingsley · Journal of Complementary and Alternative Medical Research · 2022

Objective: Twenty to 30 percent of children in cross-sectional studies have significant bedtime problems or night waking. Melatonin, a synthetic form of the hormone produced by the pineal gland as a biomarker of the circadian system, is a commonly used nonprescription pharmacolog...

Open access Research Article 10.9734/jocamr/2022/v18i130344

Differential Viability in Alpha-MEM Culturing Media May Predict Alternative Media Responsiveness in Dental Pulp Stem Cell (DPSC)

Crystal Viss, Gavin Banning, Sarah Swanbeck & Karl Kingsley · Journal of Advances in Biology & Biotechnology · 2022

  Objective: Dental pulp stem cells (DPSC) are the subjects of new and emerging fields of clinically applied biotechnology. However, much remains unknown regarding the most effective and appropriate methods for isolation, expansion and culture techniques for DPSC. To address thes...

Open access Research Article 10.9734/jabb/2022/v25i330269

Screening for Selenomonas Noxia and Akkermansia Muciniphila from the Oral Cavity of Pediatric Patients

Tommy Le, Eunice Chun, Ivan Lopez, Karl Kingsley & Linh Nguyen · Microbiology Research Journal International · 2021

Introduction: The human digestive tract is composed of an immense variety of microorganisms, which have been linked to many health problems such as obesity. There are many studies that demonstrate the association of cariogenic pathogens in dental patients and overall health. Sele...

Open access Research Article 10.9734/mrji/2021/v31i730331

Oral Site Specific Sampling Reveals Differential Location for Scardovia wiggsiae

Graydon Carr, Arvin Alexander, Linh Nguyen & Karl Kingsley · Microbiology Research Journal International · 2020

Introduction: The newly discovered cariogenic pathogen Scardovia wiggsiae has been the subject of intense scientific interest due to the role it may play in the development or progression of caries and oral disease. The primary objective of this study was to perform DNA microbial...

Open access Research Article 10.9734/mrji/2020/v30i130189

Quantitative Comparison of Oral Site-specific DNA Isolates Reveals Differential Outcomes

Graydon Carr, Arvin Alexander, Kevin Dionisio & Karl Kingsley · Journal of Advances in Biology & Biotechnology · 2019

Introduction: More and more evidence has accumulated that suggests salivary sampling may provide direct analysis of oral conditions and microbial constituents, but may also be useful in the diagnosis and early detection of other chronic diseases. Although multiple methods of oral...

Open access Research Article 10.9734/jabb/2019/v22i330116

Differential miRNA Expression in Oral Cancer Oncosomes: A Pilot In vitro Study

Dannica Brennan, Kunal Patel, Nicole Howard, Karl Kingsley & Katherine Howard · International Research Journal of Oncology · 2018

Aims: Exosomes are small membranous secreted vesicles (30-120 nm) believed to function as intercellular messengers delivering their cargo of RNA and protein to target cells. While many cells secrete exosomes, cancer cells have been found to produce higher numbers of exosomes than...

Open access Research Article

Oral Microbial Ecology of Selenomonas noxia and Scardovia wiggsiae

Steven McDaniel, Jaydene McDaniel, Amy Tam, Karl Kingsley & Katherine M. Howard · Microbiology Research Journal International · 2017

Objectives: Selenomonas species such as S. noxia are associated with poor oral health and oral prevalence of this organism may be useful as a biomarker to determine patient oral health. Current studies are now revealing novel insights into the epidemiology of the newly discovered...

Open access Research Article 10.9734/MRJI/2017/36110

Screening a Saliva Repository for Scardovia wiggsiae and Streptococcus mutans: A Pilot Study

Jaydene McDaniel, Steven McDaniel, Amy Tam, Karl Kingsley & Katherine M. Howard · Journal of Advances in Microbiology · 2017

Introduction: Many studies have evaluated the prevalence of cariogenic pathogens among dental school patients, most notably the Gram-positive organism Streptococcus mutans (SM). Recent evidence has suggested another cariogenic pathogen Scardovia wiggsiae (SW) may also be present...

Open access Research Article 10.9734/JAMB/2017/36111

Comparing the Incidence and Prevalence of Oral Microbial Pathogens Selenomonas noxia and Streptococcus mitis within the UNLV-SDM Clinical Patient Population

Namgu Kim, Melissa Trumbo, Patrick Perkins, Kevin Foote, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley & Katherine M. Howard · International Journal of Research and Reports in Dentistry · 2021

Introduction: Selenomonas noxia (SN) is a gram-negative, anaerobic bacteria, which contributes to development and progression of periodontal disease. Some evidence now suggests Streptococcus mitis (SM), a gram-positive, facultative bacterium contributing to the etiology of dental...

Open access Research Article

Scardovia wiggsiae and Streptococcus sobrinus Prevalence among Orthodontic and Non-Orthodontic Patients

Melissa Trumbo, Namgu Kim, Beanca Jhanine Samiano, Matthew Marrujo, Patrick Perkins, Kevin Foote, Katherine M. Howard & Karl Kingsley · Microbiology Research Journal International · 2021

Background: Dental cavities or caries have been identified as among the most prevalent of preventable oral conditions. However, studies are discovering new information regarding the incidence and prevalence of several cariogenic organisms, including Streptococcus mutans (SM), the...

Open access Research Article 10.9734/mrji/2021/v31i230292