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Ezejindu Damian NNABUIHE

Publications (7)

Neuroprotective Effects of Eleveted Dose Vitamin A on the Hippocampus of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, K. Ogbuokiri Doris, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2026

Methamphetamine overstimulates brain regions such as the striatum and hippocampus by increasing neurotransmitter activity, thereby causing neurotoxicity, whereas vitamin A may help protect neurons through anti-inflammatory and neuroprotective effects. This study investigated the...

Open access Research Article 10.9734/ajrimps/2026/v15i3410

Role of Vitamin-A on the Cerebral Cortex of Adult Male Wistar Rats Exposed to Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, Ogbuokiri Doris K., Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2026

Methamphetamine (METH) can induce oxidative stress and structural injury in the cerebral cortex, whereas vitamin A participates in antioxidant defence and neural maintenance. This study evaluated the effect of low-dose vitamin A on methamphetamine-induced cortical changes in adul...

Open access Research Article 10.9734/ajbgmb/2026/v18i9564

The Role of High-Dose Vitamin A on the Amygdala of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, Ogbuokiri Doris K, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · International Neuropsychiatric Disease Journal · 2026

The amygdala, a major limbic structure, regulates emotional response, anxiety, and memory formation. Methamphetamine is known to trigger oxidative stress and neurodegeneration, whereas vitamin A possesses potent antioxidant properties that may offer neuroprotection. This study ev...

Open access Research Article 10.9734/indj/2026/v23i5578

Neuroprotective Effect of Low-Dose of Vitamin A on the Prefrontal Cortex of Methamphetamine Induced Adult Male Wistar Rats

Ezejindu Damian NNABUIHE, Alozie Osinachi Prince, Onyebu Chidinma Emilia, Udodi Sopuluchukwu Princewill, Enemuo IJEOMA, Okeke Somadina Nnamdi, K. Ogbuokiri Doris, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna & Nwodo Ndubuisi Francis · Asian Journal of Research and Reports in Neurology · 2026

Methamphetamine is a potent psychostimulant known to induce oxidative stress and neurodegeneration, particularly in the prefrontal cortex, which is responsible for executive and cognitive functions. Vitamin A, an essential antioxidant, may offer neuroprotection by modulating oxid...

Open access Research Article 10.9734/ajorrin/2026/v9i1178

Effects of Co-administration of Methamphetamine and Vitamin E on the Hippocampus of Adult Male Wistar Rats

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Doris Kasarachi Ogbuokiri, Agulanna Ambrose ECHEFULACHI, Ezejindu Cosmas Nnadozie, Nneka Alice Sunday-Nweke, Samuel Chukwudi Chime, Augustus Uchenna UGWU, Victoria Onyemachi CHUKWU, Stephanie Ifebuche Abah & Francis Ndubuisi NWODO · Asian Journal of Research and Reports in Neurology · 2025

Much attention has been given to the toxic effects of methamphetamine on humans. However, it is not clear whether this toxicity is related to vital organs such as the hippocampus; hence, the present study aimed not only to elucidate the toxic effect of methamphetamine (METH) on t...

Open access Research Article 10.9734/ajorrin/2025/v8i1128

Vitamin C and E Abrogate Myelin, Oligodendrocyte and Inflammatory Markers of Rohypnol Exposed Amygdala in Adult Rats

Joshua Izuchukwu ABUGU, Ezejindu Damian NNABUIHE, Enemuo IJEOMA, Doris Kasarachi Ogbuokiri, Agulanna Ambrose ECHEFULACHI, Darlington Kenechukwu EZEAGU, Sebastine Okechukwu Nwoko, Samuel Chukwudi Chime, Ebangah Ashutiku EGBEWATT, Eduitem Sunday Otong, Gerald Ekene APEH & Ovuoba Kenneth NWODOM · International Neuropsychiatric Disease Journal · 2025

Rohypnol, scientifically known as flunitrazepam, is a potent benzodiazepine medication primarily prescribed for the treatment of severe insomnia and as a pre-anesthetic medication. However, its reputation has been tarnished by its misuse as a recreational drug and its association...

Open access Research Article 10.9734/indj/2025/v22i3487

Neuroprotective Effects of Vitamin B Complex on the Hippocampus and Prefrontal Cortex of Methamphetamine - Induced Adult Male Wistar Rats

PETER OKPE AGWU, Ukoha Ukoha & Ezejindu Damian NNABUIHE · International Neuropsychiatric Disease Journal · 2025

Methamphetamine is a potent central nervous system stimulant that causes profound neurotoxic effects on the hippocampus and prefrontal cortex, regions critical for memory, cognition, and emotional regulation. This study investigated the protective role of vitamin B complex agains...

Open access Research Article 10.9734/indj/2025/v22i6531