El-Sayed Akool

Concomitant Administration of Rosuvastatin and Lefleunamide in Low doses Synergize Against Complete Freunds Adjuvant (CFA)-Induced Rheumatoid Arthritis in Experimental Model

Abdel-Aziz Saeed, Mohamed El-Shafey, Gouda K. Helal & El-Sayed Akool · Journal of Pharmaceutical Research International · 2021

Aim: The present work was designed to examine of the potential anti-inflammatory effect of rosuvastatin (ROSV) and/or Lefleunamide (LFLU) against Complete Freunds Adjuvant (CFA)-induced arthritis in rats. Methods: The mRNA level of perxisome proliferator-activated receptor-alpha...

Open access Research Article 10.9734/jpri/2021/v33i42A32415

Molecular Mechanisms of the Modulatory Effect of Vitamin E on Tacrolimus (FK506)-Induced Renal Injury in Rats

Hassan Afify, Abdel-Aziz Abdel-Aziz, Mahmoud El-Din, Amany Balah & El-Sayed Akool · British Journal of Pharmaceutical Research · 2016

Aim: This study was designed to evaluate the possible modulatory effect of vitamine E on tacrolimus (FK506)-induced renal injury in rats. Methods: Twenty-four male Wistar rats (6 animals in each group) were used in this study. The first group (Control) received normal saline intr...

Open access Research Article 10.9734/bjpr/2016/21684