Eke Ugorji Iheanacho

Effect of Carica Papaya (Paw-Paw) Leaf Extract on the Histology of the Pancreas in the Tramadol-Induced Male Wistar Rats

Johnson Agbai Ukwa, Faustina Chiamaka Irozulike, Uchenna Azunna, Cosmas Sopuruchi Agim, Eke Ugorji Iheanacho, Eberechukwu Lolly Mbanaso, Kelechi Uzoma Akataobi & Eminence David Acha · International Research Journal of Gastroenterology and Hepatology · 2026

Tramadol, a synthetic opioid analgesic, is frequently misused for non-medical purposes, resulting in several adverse effects, including pancreatic toxicity. The pancreas, due to its dual exocrine and endocrine functions, is highly vulnerable to drug-induced oxidative stress and i...