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Ejiogu Ikedichukwu Chibueze

Publications (7)

Cardioprotective Potentials of Ethanolic Seed Extract of Persea americana on Doxorubicin-Induced Male Wistar Rats

Ejiogu Ikedichukwu Chibueze, Maduka Hugh Clifford Chima & Maduka Ignatius Chukwudi · Journal of Complementary and Alternative Medical Research · 2025

Cardiovascular diseases are the leading cause of deaths worldwide. Persea americana seed has been used for its antioxidant, anti-dyslipidemic, anti-inflammatory and anti-microbial properties. The health benefits of avocado seeds stem from essential nutrients and phytochemicals. T...

Open access Research Article 10.9734/jocamr/2025/v26i2628

Effects of Persea americana Seed Extract on Lipid Profile, Atherogenic and Coronary Risk Indices in Doxorubicin-injected Male Rats

Ejiogu Ikedichukwu Chibueze, Maduka Hugh Clifford Chima & Maduka Ignatius Chukwudi · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2025

Doxorubicin (DOX) can cause disruption in the lipid profile due to free radical process. The health benefits of avocado seeds stem from essential nutrients and phytochemicals. This study aimed to assess the effects of Persea americana seed extract on lipid profile, atherogenic an...

Open access Research Article 10.9734/ajbgmb/2025/v17i3445

An investigation on the Effects of Napoleona imperialis Methanol Seed Extract on Haematological Parameters and Cardiac Function Enzymes in Albino Rats

Haruna Gambo Sunday, Ejiogu Ikedichukwu Chibueze, Doris Kasarachi Ogbuokiri, Ikechukwu Jacob Okoro & Abdullahi Muhammed Hassan · International Journal of Research and Reports in Hematology · 2024

This study was aimed at determining the effect of methanol seed extract of N. imperialison Haematological parameters and some cardiac function biomarker enzymes. The LD50 and antinutrient contents were also determined using standard methods. The experiment comprised of 25 albino...

Open access Research Article

Neuroprotective Effects of Eleveted Dose Vitamin A on the Hippocampus of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, K. Ogbuokiri Doris, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2026

Methamphetamine overstimulates brain regions such as the striatum and hippocampus by increasing neurotransmitter activity, thereby causing neurotoxicity, whereas vitamin A may help protect neurons through anti-inflammatory and neuroprotective effects. This study investigated the...

Open access Research Article 10.9734/ajrimps/2026/v15i3410

Role of Vitamin-A on the Cerebral Cortex of Adult Male Wistar Rats Exposed to Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, Ogbuokiri Doris K., Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2026

Methamphetamine (METH) can induce oxidative stress and structural injury in the cerebral cortex, whereas vitamin A participates in antioxidant defence and neural maintenance. This study evaluated the effect of low-dose vitamin A on methamphetamine-induced cortical changes in adul...

Open access Research Article 10.9734/ajbgmb/2026/v18i9564

The Role of High-Dose Vitamin A on the Amygdala of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, Ogbuokiri Doris K, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · International Neuropsychiatric Disease Journal · 2026

The amygdala, a major limbic structure, regulates emotional response, anxiety, and memory formation. Methamphetamine is known to trigger oxidative stress and neurodegeneration, whereas vitamin A possesses potent antioxidant properties that may offer neuroprotection. This study ev...

Open access Research Article 10.9734/indj/2026/v23i5578

Neuroprotective Effect of Low-Dose of Vitamin A on the Prefrontal Cortex of Methamphetamine Induced Adult Male Wistar Rats

Ezejindu Damian NNABUIHE, Alozie Osinachi Prince, Onyebu Chidinma Emilia, Udodi Sopuluchukwu Princewill, Enemuo IJEOMA, Okeke Somadina Nnamdi, K. Ogbuokiri Doris, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna & Nwodo Ndubuisi Francis · Asian Journal of Research and Reports in Neurology · 2026

Methamphetamine is a potent psychostimulant known to induce oxidative stress and neurodegeneration, particularly in the prefrontal cortex, which is responsible for executive and cognitive functions. Vitamin A, an essential antioxidant, may offer neuroprotection by modulating oxid...

Open access Research Article 10.9734/ajorrin/2026/v9i1178