Mechanistic Insight of Transient Receptor Potential Melastatin 8 Role in Streptozotocin Induced Diabetic Nephropathy
Doaa Hussein Zineldeen, Naglaa Ibrahim Sarhan, Nahid Mohamed Tahoon & Rania El-Sayed Wasfy · International Journal of Biochemistry Research & Review · 2017
Background: The transient receptor potential melastatin 8 (TRPM8) channel is a cold-sensing non-selective cation channel involved in cellular proliferation and signaling, yet its role in diabetic nephropathy (DN) remains poorly characterized. The TRPM8 agonist, geraniol (GE) is a...