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Charles German Ikimi

Publications (3)

Kelch-like ECH-associated Protein 1-nuclear Factor Erythroid 2-related Factor 2 Pathway Activation in Neuroprotection and Cognitive Enhancement

Onoriode Andrew Udi & Charles German Ikimi · International Neuropsychiatric Disease Journal · 2025

Neurodegenerative diseases and cognitive decline pose significant global health challenges. The Kelch-like ECH-associated protein 1 (Keap1) – nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is a master regulator of cellular defense against oxidative stress and inflamma...

Open access Research Article 10.9734/indj/2025/v22i4500

Mitochondrial Dysfunction in Chlorpromazine (Induced) Neurodegeneration

Onoriode Andrew Udi, Udo Daniel EDEIFO & Charles German Ikimi · International Neuropsychiatric Disease Journal · 2025

Chlorpromazine CPZ, a widely used antipsychotic, has been linked to neurological side effects, including tardive dyskinesia, and evidence suggests a potential for long-term neurotoxic effects. This review synthesizes findings from in vitro and in vivo studies investigating the im...

Open access Research Article 10.9734/indj/2025/v22i3481

Effects of Ethyl Acetate Fraction of Mangifera haden Seeds on Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats

Maryann Nonye Nwafor, Onyinyechi Cynthia Onyekwere, Charles German Ikimi, Chinedu Shedrack Ogunwa, Abba Babandi & Alalibo Jim Whyte · International Journal of Biochemistry Research & Review · 2024

The present study investigated the effects of ethyl acetate fraction of Mangifera haden seeds on carbon tetrachloride-induced liver damage in wistar albino rats. The phytochemical compositions and acute toxicity studies of crude extract and Mangifera haden seed fraction were dete...

Open access Research Article 10.9734/ijbcrr/2024/v33i4866