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Benedict Nzube Obinwa

Publications (5)

Chlorogenic Acid in Brain Health and Cognitive Resilience: Neuroprotective Mechanisms, Evidence, and Translational Perspectives

Benedict Nzube Obinwa & Emmanuel Anayochukwu Esom · Journal of Advances in Medical and Pharmaceutical Sciences · 2026

Chlorogenic acid (CGA), a phenolic ester formed between caffeic acid and quinic acid, is one of the most abundantly consumed dietary polyphenols, found in high concentrations in green coffee beans, various fruits, and vegetables. Over the past two decades, a substantial body of p...

Open access Research Article 10.9734/jamps/2026/v28i10900

Ameliorative Effects of the Ethanolic Extract of Brassica oleracea on Naphthalene-Induced Cerebellar Toxicity in Adult Male Wistar Rats

Mmanesochi Chieze Mbonu, Agnes Akudo Nwakanma, Benedict Nzube Obinwa & Wali Catherine Chukwumuanya · Journal of Advances in Medical and Pharmaceutical Sciences · 2026

Aim: To investigate the ameliorative effects of Brassica oleracea against naphthalene-induced oxidative stress in the cerebellum of adult male Wistar rats. Methodology: Twenty five (25) adult male Wistar rats were randomly divided into five groups (A–E, n = 5). Group A served as...

Open access Research Article 10.9734/jamps/2026/v28i1841

Neuroprotective Effects of Eleveted Dose Vitamin A on the Hippocampus of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, K. Ogbuokiri Doris, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2026

Methamphetamine overstimulates brain regions such as the striatum and hippocampus by increasing neurotransmitter activity, thereby causing neurotoxicity, whereas vitamin A may help protect neurons through anti-inflammatory and neuroprotective effects. This study investigated the...

Open access Research Article 10.9734/ajrimps/2026/v15i3410

Role of Vitamin-A on the Cerebral Cortex of Adult Male Wistar Rats Exposed to Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, Ogbuokiri Doris K., Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · Asian Journal of Biochemistry, Genetics and Molecular Biology · 2026

Methamphetamine (METH) can induce oxidative stress and structural injury in the cerebral cortex, whereas vitamin A participates in antioxidant defence and neural maintenance. This study evaluated the effect of low-dose vitamin A on methamphetamine-induced cortical changes in adul...

Open access Research Article 10.9734/ajbgmb/2026/v18i9564

The Role of High-Dose Vitamin A on the Amygdala of Adult Male Wistar Rats Exposed to Toxic Doses of Methamphetamine

Ezejindu Damian NNABUIHE, Joshua Izuchukwu ABUGU, Enemuo IJEOMA, Okeke Somadina Nnamdi, Ogbuokiri Doris K, Okeke Henry Kachikwuru, Ekoh Augustine Alobu, Benedict Nzube Obinwa, Chinyere Elizabeth Eze, Nwaefulu Kester Eluemunor, Sobanke A. Omolara, Chidinma Ifeyinwa Mmaju, Okafor Anulika Jacinta, Chuka-Onwuokwu Ngozi Cynthia, Ejiogu Ikedichukwu Chibueze, Nwoko Sebastine Okechukwu, Wuraola Serah Nnaemeka, Ebi Victory Chinecherem, Agu Augustine Uchenna, Ugwu Augustus Uchenna, Nwodo Ndubuisi Francis, Elemuo Chukwuebuka Stanley, Agbai Johnson Ukwa, Muorah Chinecherem Onyekachi & Ozoemena Chiadikobi Lawrence · International Neuropsychiatric Disease Journal · 2026

The amygdala, a major limbic structure, regulates emotional response, anxiety, and memory formation. Methamphetamine is known to trigger oxidative stress and neurodegeneration, whereas vitamin A possesses potent antioxidant properties that may offer neuroprotection. This study ev...

Open access Research Article 10.9734/indj/2026/v23i5578