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Benedict C. Umezurike

Publications (4)

Genetic Insights and Epidemiological Models in Understanding Primary Open Angle Glaucoma

Benedict C. Umezurike, Moses O. Akhimien, Chidinma Chukwuka, Thaddaeus C. Ejike, Louis Ugwulor, Bright Ajoku & Solomon N. Ijioma · Ophthalmology Research: An International Journal · 2024

Primary open-angle glaucoma (POAG) is a multifactorial chronic optic neuropathy with significant genetic heterogeneity. The pathogenesis of POAG involves an imbalance between the production and drainage of aqueous humor (AH). Genetic theories suggest that transgenic mice demonstr...

Open access Research Article 10.9734/or/2024/v19i6440

The Genetics of Primary Open Angle Glaucoma Interventions: Therapeutic Directions and Future Predictions

Benedict C. Umezurike, Moses O. Akhimien, Chidinma Chukwuka, Thaedus Ejike, Louis Ugwulor, Bright Ajoku & Solomon N. Ijioma · Ophthalmology Research: An International Journal · 2024

The “multifactorial chronic optic neuropathy” known as primary open angle glaucoma (POAG) is typified by a “progressive loss of retinal ganglion cells (RGC), structural damage to the retinal nerve fiber layer (RNFL) and optic nerve head (ONH), as well as abnormalities in the visu...

Open access Research Article 10.9734/or/2024/v19i5435

Primary Open Angle Glaucoma: The Pathophysiolgy, Mechanisms, Future Diagnostic and Therapeutic Directions

Benedict C. Umezurike, Moses Obeimen Akhimien, Okechukwu Udeala, Uzoamaka G. Green, Ugonma Okpechi-Agbo & Maureen U. Ohaeri · Ophthalmology Research: An International Journal · 2019

Primary open angle glaucoma (POAG) is a multifactorial chronic optic neuropathy, characterized by progressive loss of retinal ganglion cells (RGC), leading to structural damage to the optic nerve head (ONH), retinal nerve fiber layer (RNFL), with  visual field defects. It is occa...

Open access Research Article 10.9734/or/2019/v10i330106

The Pathogenesis of Index Myopia in Hyperglycemia in Type 2 Diabetes: A Review

Benedict C. Umezurike, Okechukwu Udeala, Uzoamaka G. Green, Ugonma Okpechi-Agbo & Maureen U. Ohaeri · Ophthalmology Research: An International Journal · 2018

Elevated blood glucose or hyperglycemia occasioned by Diabetes Mellitus (DM), compromises the index of refraction of the crystalline lens, due to the osmotic difference between the lens materials and the aqueous medium of the anterior chamber of the eye. Under this circumstance t...

Open access Research Article 10.9734/OR/2018/42436