Background: The equation of the difference between reverse and forward Gibbs free energy of activation (ΔΔGES#) reflects Michaelis-Menten constant (KM) in both directions; this may not be applicable to all enzymes even if the reverse reaction is speculatively Michaelian. Arrheniu...
Open access
Research Article10.9734/ajopacs/2019/v7i430103
Background: It is not unusual to observe calculated “total” free enzyme ([E]) in enzyme catalysed reaction, but this should include total enzyme-substrate complex ([EST]) which accounts for sequestration. Objectives: 1) To show indirectly that the velocities of catalytic action c...
Open access
Research Article10.9734/ajrb/2019/v5i430098
Background: Targeting of macromolecules by means of translational diffusion for therapeutic reason is generally of interest. But translational velocity that enables directional delivery of any molecule on target is given less attention. Objectives: The objectives of this research...
Open access
Research Article10.9734/ajrb/2019/v5i330089
Background: There seems to be a mathematical or a conceptual error in an equation whose substitution into other equations for the determination of an apparent hydrated molar volume (V1) of a cosolute leads to an incorrect answer. Objectives: The objectives are 1) To show theoreti...
Open access
Research Article10.9734/ajrb/2019/v5i230087
Background: There may be dry enzymes, but water remains indispensable for the catalytic action of enzymes. There is not as much interest in how the presence of a drug such as aspirin and a psychoactive compound such as ethanol may affect the water-mediated role of the enzyme. Obj...
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Research Article10.9734/ajrb/2019/v5i230085
Background: Researchers who have shown interest in the consequence of introducing dry biomolecules or a solution of it into cosolvents generally known as osmolyte, have applied many models for the elucidation of the scientific basis of the results obtained. The Kirkwood and Buff...
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Research Article10.9734/ajopacs/2019/v7i130086
Aims: The objectives of the in vitro study were to examine the applicability of thermodynamic models for the interaction of reaction mixture components to enzyme catalyzed reaction, and to determine the effect of co – solutes on the velocity of hydrolysis of a substrate with alph...
Open access
Research Article10.9734/AIR/2016/24269