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A. R. T. Pupulin

Publications (7)

Organotherapic Medicine Improves Blood Glucose Levels in AIDS Patients

A. R. T. Pupulin, L. Mortean & M. Spack Jr · Journal of Advances in Medicine and Medical Research · 2014

Aims: To evaluate the effect of an organotherapic drug, produced from the pancreas of a young pig, on glycemic alterations in AIDS patients. Methodology: Current study was carried out in a double-blind, placebo controlled and randomized design. AIDS patients who had high fasting...

Open access Research Article 10.9734/BJMMR/2015/14036

Effect of Delphinium staphisagria in Murine Infection by Myocoptes musculinus

W. C. Eibel, F. Otomura & A. R. T. Pupulin · Journal of Pharmaceutical Research International · 2014

Biomedical investigations still rely on the use of laboratory animals, mice and rats are the most commonly used on experimentations. Past experimentations with these animals showed that they could be affected by environmental conditions and infections, causing interferences on re...

Open access Research Article 10.9734/BJPR/2014/14294

Effects of Melatonin on Metabolic Abnormalities in HIV Patients Treated with Antiretroviral Drugs

F. R. Nerone, G. F. Messias, M. Spack Jr & A. R. T. Pupulin · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Aims: Highly Active Antiretroviral Therapy (HAART) is the current care standard for treating patients with HIV/AIDS. Although HAART has is the only regimen potent enough to decrease viral load, adverse events may limit its efficacy. Metabolic disorders are common in patients trea...

Open access Research Article 10.9734/jamps/2019/v21i130121

Effects of Melatonin on Level of Cytokine in Patients with AIDS

F.R. Nerone, F.N. Ferraz, P.F.B. Mendonça, M. Spack Jr & A. R. T. Pupulin · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Aims: Changes in cytokine levels in HIV infected individuals can affect the function of the immune system and have the potential to directly impact the course of HIV disease by enhancing or suppressing HIV replication. Melatonin influences various immune cells, including lymphocy...

Open access Research Article 10.9734/jamps/2025/v27i4767

Effects of Dilutions of Apis mellifera on Metabolic Abnormalities Induced by Antiretroviral Therapy in Mice

M. L. Recco, T. Sakurada Jr, L. A. Jagas, M. Spack Jr & A. R. T. Pupulin · Journal of Complementary and Alternative Medical Research · 2018

Background: Highly Active Antiretroviral Therapy (HAART) is associated with significant mortality decreased and risk in AIDS progression. However, complications due to long-standing HIV infection and treatment have become increasingly important. Complications include hepatic and...

Open access Research Article 10.9734/JOCAMR/2018/43701

Effect of Homeopathic Drug on Metabolic Abnormalities Induced by HAART in Mice

N. A. Steiner, A. L. P. P. Soares, R. P. Regla, M. Spack Jr & A. R. T. Pupulin · Asian Journal of Research in Medical and Pharmaceutical Sciences · 2018

Aims: Highly Active Antiretroviral Therapy (HAART) increased survival of AIDS patients. HAART-associated major toxic effects comprised: neuropathy, myopathy, pancreatitis, hepatic steatosis, lactic acidosis and lipoatrophy, metabolic complications (fat redistribution, insulin res...

Open access Research Article 10.9734/AJRIMPS/2017/38024

Microbicidal Activity of Neutrophils Isolated from HIV Patients

J. B. Borges, T. Sakurada Jr, N. C. S. Santana, N. A. Lima, S. Lautenschlaugher & A. R. T. Pupulin · International Blood Research & Reviews · 2015

HIV infection is associated with a progressive loss of T cell functional capacity and reduced responsiveness to antigenic stimuli. Neutrophils are crucial cellular components of the innate immune system. Current study evaluates the functional activity of neutrophils isolated from...

Open access Research Article 10.9734/IBRR/2015/16929