A. R. T. Pupulin

Effects of Melatonin on Metabolic Abnormalities in HIV Patients Treated with Antiretroviral Drugs

F. R. Nerone, G. F. Messias, M. Spack Jr & A. R. T. Pupulin · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Aims: Highly Active Antiretroviral Therapy (HAART) is the current care standard for treating patients with HIV/AIDS. Although HAART has is the only regimen potent enough to decrease viral load, adverse events may limit its efficacy. Metabolic disorders are common in patients trea...

Open access Research Article 10.9734/jamps/2019/v21i130121

Effects of Melatonin on Level of Cytokine in Patients with AIDS

F.R. Nerone, F.N. Ferraz, P.F.B. Mendonça, M. Spack Jr & A. R. T. Pupulin · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Aims: Changes in cytokine levels in HIV infected individuals can affect the function of the immune system and have the potential to directly impact the course of HIV disease by enhancing or suppressing HIV replication. Melatonin influences various immune cells, including lymphocy...

Open access Research Article 10.9734/jamps/2025/v27i4767

Microbicidal Activity of Neutrophils Isolated from HIV Patients

J. B. Borges, T. Sakurada Jr, N. C. S. Santana, N. A. Lima, S. Lautenschlaugher & A. R. T. Pupulin · International Blood Research & Reviews · 2015

HIV infection is associated with a progressive loss of T cell functional capacity and reduced responsiveness to antigenic stimuli. Neutrophils are crucial cellular components of the innate immune system. Current study evaluates the functional activity of neutrophils isolated from...

Open access Research Article 10.9734/IBRR/2015/16929