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Biochemistry

Papers (4)

Consecutive Four-Component Coupling-Addition Aza-Anellation Pictet–Spengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

Kai Ries, Françoise A. Aouane & Thomas J. J. Müller · Organics · 2023

Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction. In this study, the aza-Michael addition step to generate intermediate enaminones was optimized in the pre...

Open access Research Article 10.3390/org4030025

A Novel Class of Functionally Tuneable Star-Shaped Molecules for Interaction with Multiple Proteins

Debashis Barik, Geethanjali Anand, Subba Rao Cheekatla & Mintu Porel · Organics · 2023

Molecules with tuneable properties are well known for their applications in the material and bio-medical fields; nevertheless, the structural and functional tunability makes them more significant in diverse applications. Herein, we designed and synthesized a novel class of star-s...

Open access Research Article 10.3390/org4020018

Synthesis of Amino-Acid-Based Nitroalkenes

Velisaria-Eleni Gerogianni, Giorgos S. Koutoulogenis, Dimitrios Triantafyllos Gerokonstantis & George Kokotos · Organics · 2022

Fatty-acid-based nitroalkenes have recently received great attention because of their bioactivities. On the contrary, peptide- or amino-acid-based nitroalkenes have been scarcely explored so far, although they may exhibit interesting biological properties, for example, as enzyme...

Open access Research Article 10.3390/org3020011

Haematological and Biochemical Changes Associated with Treatment of Experimentally-Induced Hypertensive Wistar Rats with Lagenaria breviflora Roberty Fruit or Xanthosoma sagittifolium Exell Corm

Olayinka A. Oridupa, Feyisola L. Ojojugbo & Naomi O. Ovwighose · Annual Research & Review in Biology · 2018

Aim: The toxicity profile of management of hypertension in Wistar rats with the methanol extracts of the whole fruit of Lagenaria breviflora Roberty or corms of Xanthosoma sagittifolium was assessed in this study. Place and Duration of Study: The study was carried out at the Anim...

Open access Research Article 10.9734/ARRB/2018/36336