artemisinin resistance

Sentinel surveillance of the WHO-Validated Pfkelch13 C580Y Artemisinin Resistance Marker in Plasmodium falciparum Isolates from Bangui, Central African Republic

Moynam Ekte Heredeibona, Aroun Abdel Nassir, Bejendo Dan-Houron, Héritier Obed Lango, Christelle Luce Bobossi, Coretha Bokia Baguida, Ernest Lango-Yaya, Boniface Koffi, Emile Minyaka & Romaric NzoumbouBoko · Microbiology Research Journal International · 2026

Background: Artemisinin-based combination therapies (ACTs) are the cornerstone of malaria treatment. However, partial artemisinin resistance associated with mutations in the Plasmodium falciparum Pfkelch13 propeller domain threatens malaria control efforts. The C580Y substitution...

Open access Research Article 10.9734/mrji/2026/v36i61751

Molecular Determinants of Artemisinin Resistance in k13 Gene of Plasmodium falciparum

Zaw Lin & Myo Thura Zaw · Microbiology Research Journal International · 2015

Artemisinin-based combination therapy (ACT) is the first-line therapy in most malaria endemic countries. An impressive 47% reduction in the global mortality rate between 2000 and 2013 has been achieved by ACT and artemisinin (ART) monotherapy. However, artemisinin resistance (AR)...

Open access Research Article 10.9734/BMRJ/2015/18776