Annulation

Synthesis of 3-Hydroxy-9H-fluorene-2-carboxylates via Michael Reaction, Robinson Annulation, and Aromatization

Yu-Min Wang, Yi-Hung Liu & Shiuh-Tzung Liu · Organics · 2022

A series of 3-hydroxy-fluorene-2-carboxylate compounds were prepared from Michael addition of acetoacetate to 2-benzylideneindan-l-one followed by Robinson annulation and aromatization. In this reaction, we were able to isolate two Robinson annulation products and characterize th...

Open access Research Article 10.3390/org3040031

Synthesis of 1-Trifluorometylindanes and Close Structures: A Mini Review

Olesya V. Khoroshilova & Aleksander V. Vasilyev · Organics · 2021

This review describes methods for the synthesis of 1-trifluomethylindanes and close structures, which are still quite rare and scarcely available compounds. There are two main approaches to obtain 1-CF3-indanes. The first one is the construction of an indane system from CF3 precu...

Open access Research Article 10.3390/org2040019