Aims: To report an adolescent with drug-resistant focal epilepsy who developed super-refractory epilepsia partialis continua (EPC), in the setting of suspected Rasmussen syndrome, highlighting diagnostic and management challenges in a resource-limited setting. Case Presentation:...
Open access
Research Article10.9734/ajorrin/2026/v9i1196
Background: Inflammatory demyelinating disorders of the central nervous system may present with overlapping clinical and radiological features, particularly when the initial event is confined to the brainstem. Isolated periaqueductal midbrain involvement presenting with binocular...
Open access
Research Article10.9734/ajorrin/2026/v9i1195
Huntington’s disease is a progressive neurodegenerative disorder characterised by motor, cognitive, psychiatric, and functional deterioration. Conventional assessment using genetic information, clinical scales, neuroimaging, and molecular biomarkers provides important information...
Open access
Research Article10.9734/ajorrin/2026/v9i1194
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory impairment, and oxidative stress. Aim: This study investigated the neuroprotective effects of the butanol fraction of Zapoteca portoricensis root (BFZP) in...
Open access
Research Article10.9734/ajorrin/2026/v9i1193
Children and adolescents receive antiseizure medications and antipsychotics for prolonged periods during the developmental window in which linear growth, bone mineral accrual, pubertal maturation and metabolic set points are established. Endocrine and auxological adverse effects...
Open access
Research Article10.9734/ajorrin/2026/v9i1192
Alcohol is one of the most widely consumed psychoactive substances worldwide, with increasing reports of consumption during pregnancy. The hippocampus is one of the brain regions most vulnerable to its effects. However, there is a paucity of research on the histomorphometric and...
Open access
Research Article10.9734/ajorrin/2026/v9i1191
Background: Fingolimod is an oral disease-modifying therapy approved for the treatment of highly active relapsing forms of multiple sclerosis (MS). Real-world data remain essential for assessing its long-term effectiveness and safety in routine clinical practice. Objective: The s...
Open access
Research Article10.9734/ajorrin/2026/v9i1190
Aims: To present the diagnostic differentiation and multidisciplinary neuro-renal nursing management of a rare, life-threatening presentation of Neuromyelitis Optica Spectrum Disorder (NMOSD) complicated by advanced Stage 4 chronic kidney disease (CKD). Presentation of Case: A 42...
Open access
Research Article10.9734/ajorrin/2026/v9i1189
Background: Anti-CD20 monoclonal antibodies, including rituximab (RTX) and ocrelizumab (OCR), have markedly improved the management of multiple sclerosis (MS) by reducing inflammatory disease activity. However, local evidence regarding their effectiveness and safety in real-world...
Open access
Research Article10.9734/ajorrin/2026/v9i1187
This study investigated the effect of cadmium exposure and Annona muricata (soursop) leaf extract on the cortical histology of adult albino rats. Cadmium is a recognised environmental toxicant capable of inducing neurodegeneration through oxidative stress and inflammatory pathway...
Open access
Research Article10.9734/ajorrin/2026/v9i1188
Climate change is altering the environmental cycling of a diverse range of contaminants, with consequences for their bioaccumulation in food webs and their neurotoxic potential in wildlife and humans. Rising temperatures, permafrost and glacial thaw, wildfire activity, sea level...
Open access
Research Article10.9734/ajorrin/2026/v9i1186
Aims: The use of medicinal plants in sub-Saharan Africa raises concerns regarding neurological safety. This study evaluated the effects of sub-chronic oral administration of ethanolic leaf extracts of Rauwolfia vomitoria (RV) and Gongronema latifolium (GL), singly and in combinat...
Open access
Research Article10.9734/ajorrin/2026/v9i1185
Cannabis remains the most widely used controlled substance worldwide, and its relationship with common and severe mental disorders continues to generate scientific and public health debate. This narrative review synthesises evidence published across pharmacological, epidemiologic...
Open access
Research Article10.9734/ajorrin/2026/v9i1184
Scrub typhus is an endemic zoonotic infection within the Tsutsugamushi Triangle and is an important cause of acute febrile illness with variable systemic and neurological manifestations. Guillain-Barré syndrome (GBS) is an uncommon peripheral nervous system complication, and bila...
Open access
Research Article10.9734/ajorrin/2026/v9i1183
Creutzfeldt-Jakob disease is a rare, rapidly progressive prion disorder that most commonly presents with cognitive decline, myoclonus, cerebellar signs, and other neuropsychiatric manifestations. Atypical presentations may delay recognition, particularly when the initial clinical...
Open access
Research Article10.9734/ajorrin/2026/v9i1182