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All published articles 145

Leydig Cell Tumor Presenting as Peripheral Precocious Puberty in a Six-Year-Old Boy: A Case Report and Literature Review

Girin Ray & Debmalya Sanyal · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Leydig cell tumour is an uncommon cause of gonadotropin-independent precocious puberty in prepubertal boys. Case Presentation: A 6-year-3-month-old boy presented with a three-month history of progressive penile enlargement and pubic hair development, without axillary...

Open access Research Article 10.9734/ajrre/2026/v9i1146

Anti-Infertility Effects of Ocimum gratissimum and Vernonia amygdalina on Carbon Tetrachloride-Induced Toxicity in the Reproductive System of Wistar Rats

D. I. Izunwanne & E. E. Ekpo · Asian Journal of Research and Reports in Endocrinology · 2026

Introduction: Male infertility associated with exposure to environmental toxicants has become a significant public health concern worldwide. Carbon tetrachloride (CCl₄), a widely recognised industrial pollutant, is known to induce severe reproductive toxicity through oxidative st...

Open access Research Article 10.9734/ajrre/2026/v9i1145

Disease Management and Treatment Adherence Outcomes among Hypertensive and Diabetic Patients in a Semi-rural Hospital, Akwanga, Nasarawa State, Nigeria

A. Nyamve, I. H. Nkene, S. C. Tama, S. K. Bello & S. C. Hassan · Asian Journal of Research and Reports in Endocrinology · 2026

Aims: This study assessed disease management and treatment adherence outcomes among hypertensive and diabetic patients attending Our Lady of Apostle (OLA) Hospital, a semi-rural healthcare facility in Akwanga, Nasarawa State, Nigeria, and examined the barriers patients face in ac...

Open access Research Article 10.9734/ajrre/2026/v9i1144

Effects of Different Types of Toothpaste on Fasting Blood Glucose Levels in Diabetic Individuals: A Systematic Review of Pre-Test/Post-Test Studies

Jacques Forwah Ndeh, Edung Emem Samuel, Benjamin Essien, Bassey Okon Bassey, Ughwusuena Ufuoma Louis, Ramatu Umar Ibrahim, Eunice Akomu Aji, Ewa Anthony Obi, Idiege Idiege Omang, Akaba Kingsley Onoridea, Ugwuanyi Ifeanyichukwu Samson, Makata, Rex Oseloka, Promise Chika Kemas-Uneze, Jane Ulifo Falade, Wisdom Effiong, David Ikechukwu Achuzia, Oluwaseun Abiodun Oloyede, Isoboye, Manuel Bokoye, Nnaji Chimuanya Joseph, Immaculate Ihuoma Ekeagba & Abeshi Sylvester Etenikang · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Toothpastes marketed as sugar-free, herbal, probiotic, paraprobiotic or diabetes-specific are sometimes presumed to influence glycaemia. The evidence relevant to fasting blood glucose (FBG), however, is easily conflated with studies of salivary glucose or periodontal...

Open access Research Article 10.9734/ajrre/2026/v9i1143

Predictors of Self-care Practices among Patients with Type 2 Diabetes in Ghana: The Role of Illness Perception and Diabetes Knowledge

Perpetua Kessie-Mensah, Etepe Kofi Dugah, Gloria Ohene Takyi, Yaw Manu Boateng, Mustapha Bin Usman, Paul Gyan, Martha Masata Adeyiga, Wollie Kwadwo Abraham, Isaac Asamoah Abekah, Eunice Ansaa Anafi, Patricia Pearl Ankrah & Yaa Gyaa Fynn · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Type 2 diabetes mellitus requires continuous self-care across diet, physical activity, blood-glucose monitoring, foot care and medication use. Evidence from Ghana and sub-Saharan Africa shows persistent gaps in diabetes self-management, partly because biomedical advic...

Open access Research Article 10.9734/ajrre/2026/v9i1142

Testosterone, Aggressive Behaviour and Social Decision-making: A Critical Integrative Narrative Review

Ahmad Majed Sallah · Asian Journal of Research and Reports in Endocrinology · 2026

Testosterone is frequently described as an aggression-promoting hormone, yet this shorthand obscures a literature in which effects are small, context-dependent and sometimes prosocial. This critical narrative review evaluates evidence linking endogenous testosterone, competition-...

Open access Research Article 10.9734/ajrre/2026/v9i1141

Precision Medicine in Diabetes Mellitus: A Critical Narrative Review of Diagnostic, Therapeutic and Implementation Advances

K. Roshini, M. Saru Niveditha & S. Dharani · Asian Journal of Research and Reports in Endocrinology · 2026

Diabetes mellitus is no longer understood as a single disease but as a heterogeneous collection of conditions unified by chronic hyperglycaemia and diverging in aetiology, pathophysiology, clinical trajectory and treatment response. Precision medicine seeks to exploit this hetero...

Open access Research Article 10.9734/ajrre/2026/v9i1139

The Use of Human Chorionic Gonadotropin and Testosterone in Adolescents with Constitutional Delay of Growth and Puberty and Hypogonadism: A Critical Narrative Review

Ashraf Soliman, Fawzia Alyafei, Nada Alaaraj, Noor Hamed, Shayma Ahmed & Ahmed Elawwa · Asian Journal of Research and Reports in Endocrinology · 2026

Delayed puberty in adolescent boys arises most commonly from a self-limited maturational variant, constitutional delay of growth and puberty, but must be distinguished from permanent hypogonadotropic or hypergonadotropic hypogonadism before hormonal treatment is selected, because...

Open access Research Article 10.9734/ajrre/2026/v9i1140

Effect of a Three-Month Exercise Regime on Androgens and Sex Hormone-binding Globulin of Premenopausal Students of Nnamdi Azikiwe University, Nnewi, Nigeria

C. M. Njoku, S. C. Meludu, A. J. Onuegbu, M. J. Olisekodiaka, N. O. Osakue, C. C. Onyenekwe & E. N. Osakue · Asian Journal of Research and Reports in Endocrinology · 2026

Background: There is traditional conviction that if premenopausal women engage in prolonged physical exercise, they are likely to become masculinized and develop infertility. Androgens, although traditionally thought to be male sex steroids, play important roles in female reprodu...

Open access Research Article 10.9734/ajrre/2026/v9i1138

Moringa oleifera Effects on Male and Female Reproductive Organ Histology and Hormonal Profile in Adult Wistar Rats

Mary Adeola Olugbenga, William A. Adisa, Opeyemi Jolade Olabanji, Paul Nwabor Ekibade, Matthew O. Okosun & Moses Odion Eromosele · Asian Journal of Research and Reports in Endocrinology · 2026

Moringa oleifera is a plant recognised for its nutritional and therapeutic value and has traditionally been used to support health, including reproductive health. This study examined the effects of aqueous Moringa oleifera leaf extract on reproductive organs, hormones, and body w...

Open access Research Article 10.9734/ajrre/2026/v9i1137

Premature Ovarian Insufficiency in Adolescents and Young Women: A Systematic Review and Meta-analysis of Etiology, Genetic Diagnostic Yield, Autoimmune Associations, and Management Outcomes

Ashraf Soliman, Fawzia Alyafei, Nada Mwafak Al Aaraj, Noor Sadeq Abdullah Hamed, Shayma Ahmed & Nada Soliman · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Premature ovarian insufficiency is characterised by impaired ovarian function before 40 years of age and may present in adolescents and young women with delayed puberty, primary or secondary amenorrhoea, incomplete pubertal progression, hypo-oestrogenism, and elevated...

Open access Research Article 10.9734/ajrre/2026/v9i1136

Early-Onset Type 1 Diabetes Mellitus in Children: A Critical Review of Pathogenesis, Epidemiology, Clinical Management, and Emerging Therapeutic Strategies

Onyinyechukwu A. R. Ayabazu & Obinna D. Nwaizuzu · Asian Journal of Research and Reports in Endocrinology · 2026

Early-onset type 1 diabetes mellitus (T1DM) in children is one of the most prevalent and clinically complex chronic autoimmune diseases of childhood, defined by progressive immune-mediated destruction of pancreatic beta cells, absolute insulin deficiency, and lifelong management...

Open access Research Article 10.9734/ajrre/2026/v9i1135

Knowledge and Symptom Burden of Diabetic Peripheral Neuropathy and Associated Demographic and Clinical Predictors in Eastern Province, Saudi Arabia

Eman M. Gaber Hassan, Myra Cusi Britiller, Mohammad Daud Ali, Reda A. Omar, Zainab Fathi Almuallim, Fatimah Ahmed Almashama, Latha S. Kannan, Shainy Daniel & Shimaa Mohammed Said · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes and contributes substantially to disability and reduced quality of life. However, limited evidence from Saudi Arabia has simultaneously examined patients’ knowledge of DPN and the...

Open access Research Article 10.9734/ajrre/2026/v9i1133

Effects of Roflumilast on Glycaemic Control, Insulin Secretion, Lipid Profile and Pancreatic Histology in Streptozotocin-Induced Diabetic Wistar Rats

Echa Raphael Akpe, M. K. Dallatu, Wali Usman, A. S. Mainasara, J. M. Bunza, Albashir Tahir, Bello, Miftahu & Muhammed Danjuma · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Diabetes mellitus (DM) is a progressive metabolic disorder characterised by persistent hyperglycaemia, impaired β-cell function, chronic inflammation and oxidative stress. Current antidiabetic therapies improve glycaemic status but may not fully address inflammatory a...

Open access Research Article 10.9734/ajrre/2026/v9i1134

Global Variation in Female Pubertal Onset, Progression, and Duration, and Biochemical Thresholds for Diagnosis: A Comparative Review across Continents and Gonadotropin–estradiol Cutoffs

Ashraf Soliman, Fawzia Alyafei, Nada Alaaraj, Noor Hamed, Shayma Mohamed & Nada Soliman · Asian Journal of Research and Reports in Endocrinology · 2026

Background: Female pubertal onset is a complex, multifactorial biological event with substantial global variation. Secular trends show progressive earlier thelarche and menarche across continents, yet biochemical thresholds for diagnosing pubertal onset and central precocious pub...

Open access Research Article 10.9734/ajrre/2026/v9i1132