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All published articles 499

In vitro and In vivo Studies on Mulberry Extracts: Evaluation of Chemical and Anticancer Activities and Attenuation of Lead Toxicity

Eman S. Ramis, Gihan M. Hammoud & Khaled M. ElSawy · Asian Journal of Research in Biochemistry · 2018

Lead (Pb) is one of the environmental pollutants. There has been a serious concern in the recent past regarding natural source for protection or curing from lead. The aim of the present study is evaluation and comparing of mulberry leaves and fruits extracts in protection from le...

Open access Research Article 10.9734/ajrb/2018/v2i3525

Retracted: An Experimental Model of Hepatic Steatosis to Detect Lipid Accumulation

Maryam Ammani Lawal, Gregory Elayeche Oko, Emmanuel Paul Okoi, Khuyen Thi Kim Vo & Shuaib Samirah Isah · Asian Journal of Research in Biochemistry · 2018

Obesity is associated with an increased risk of metabolic syndromes such as type 2 diabetes, insulin resistance, dyslipidaemia and non-alcoholic fatty liver disease. Obesity occurs as a result of an imbalance between food intake and energy expenditure leading to excessive accumul...

Open access Research Article 10.9734/ajrb/2018/v2i3497

Protective Effects of Aqueous Extract of Ocimum gratissimum on Prostate Functions in Hormonal Induced Enlarged Prostate in Adult Rats

Ugwu Melvin Nnaemeka, Ogueche, Peter Nnamdi, Eteng, Mbeh Ubana & Eno, Margaret Akpan · Asian Journal of Research in Biochemistry · 2018

Background: Benign prostatic hyperplasia (BPH) is a histological disease characterised by an increased number of epithelial cells and stromal cells within the prostate gland.  We investigated the effect of aqueous leaf extract of Ocimum gratissimum on BPH induced animal model. Me...

Open access Research Article 10.9734/ajrb/2018/v2i2468

Prostaglandins and Thromboxane Status in Patients with Cardiovascular Diseases in Ekiti State, Nigeria

M. F. Asaolu, A. A. Sonuga & S. O. Ajiboye · Asian Journal of Research in Biochemistry · 2018

Aims: Prostaglandins and Thromboxane A2 are prostanoids, with platelet aggregator and vasoconstrictor properties. This study was carried out to assess the prostaglandins and thromboxane status of patients with cardiovascular diseases in Ekiti State, Nigeria.  Study Design: This i...

Open access Research Article 10.9734/ajrb/2018/v2i3487

Effects of Crude Methanol Soluble Extract of Momordica charantia on Cancer Cell Lines and L6 Cell Line

Gunasekar Manoharan · Asian Journal of Research in Biochemistry · 2018

A multitude of plants have been used extensively for the treatment of cancers throughout the world.  In many parts of the world, especially in poor countries, this may be the only form of cancer therapy. Much research has been focused on the scientific evaluation of traditional a...

Open access Research Article 10.9734/ajrb/2018/v2i2462

Anti-snake Venom Activity of Aqueous and Ethanolic Extracts of Crinum jagus Bulb

A. H. Zailani, P. K. Magaji, S. Sarkiyayi & A. U. Wurochekke · Asian Journal of Research in Biochemistry · 2018

Aim: To determine the anti-snake venom effect of crude aqueous and ethanolic extracts and separated fractions of Crinum jagus bulb on rats injected with Echis ocellatus venom. Study Design: Evaluation of LD50 of venom, anti-lethal effects of different extract preparations and the...

Open access Research Article 10.9734/ajrb/2018/v2i2455

Therapeutic Potential of Quercetin on Biochemical Deteriorations Induced by Copper Oxide Nanoparticles

Eman R. Youness, Azza F. Arafa, Hanan F. Aly & Emad EL-Meligy · Asian Journal of Research in Biochemistry · 2018

Objective: The current research is designed to evaluate copper oxide nanoparitcles (CuO NPs) toxicity on HCT116 in vitro as well as in vivo on liver paraoxanse 1 (PON1 ) activity and serum B-cell lymphoma -2 (BCl2) in rats. Materials and Methods: The toxicological role of CuO-NPs...

Open access Research Article 10.9734/ajrb/2018/v2i2450

Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study

Samuel O. Ureme, Innocent C. Anioke & C. Igboerika · Asian Journal of Research in Biochemistry · 2018

Objective: The study investigated the possibility of using blood groups as predictive indices for diseases associated with lipid metabolism. Methods: Lipid profiles were examined in 100 apparently healthy male (40) and female (60) subjects of different ABO blood groups aged betwe...

Open access Research Article 10.9734/ajrb/2018/v2i2424

Vitamin D Deficiency and Evaluation of the Parathyroid Hormone Status in People Living with HIV in Côte d’Ivoire

Aya Jeanne Armande Aké, Lydie Boyvin, Kipré Laurent Séri, Mousso Jean Maurel Allico, Kadjoweli Djakaridja Yéo, Adou Francis Yapo & Allico Joseph Djaman · Asian Journal of Research in Biochemistry · 2018

Background: Micronutrients play an important role in the human immune system. During HIV infection, the virus utilises the micronutrients of the body, for its replication causing metabolic disorders including phosphocalcic. Parathyroid hormone (PTH), vitamin D3 (25-hydroxyvitamin...

Open access Research Article 10.9734/ajrb/2018/v2i1412

Modulations of Some Carbohydrate Metabolic Enzymes by Aqueous and Ethanol Buchholzia coriacea Seed Extract in Alloxan Induced Diabetic Rats

K. O. Gbagbeke, A. O. Naiho, P. R. C. Esegbue, M. O. Odigie & M. A. Omoirri · Asian Journal of Research in Biochemistry · 2018

Characterised by abnormal increase in blood glucose level, Diabetes is a metabolic disorder that is associated with complications in carbohydrate, protein and fat metabolism. In recent times, medicinal herbs have been implicated in traditional medical practice for the treatment o...

Open access Research Article 10.9734/ajrb/2018/v2i1402

Alterations of Tumor Suppressor Genes Expression in Colorectal Cancer: Their Impact on Progression and Prediction of Patients Outcome

Menha Swellam, Tamer E. Mosa, Mie Afify, Mohamed D. E. Abdelmaksoud & Lobna R. Ezz El Arab · Asian Journal of Research in Biochemistry · 2018

Background: Deregulation of tumor suppressor genes as APC, DCC and SMAD2 are related to tumorgenesis thus we aimed to investigate their expression among colorectal cancer to validate their relation with clinicopathological factors and the clinical outcome for CRC patients. Materi...

Open access Research Article 10.9734/ajrb/2018/v2i1394

Evaluation of Serum Levels of Endothelial Adhesion Molecules: Leukocyte Adhesion Molecule-1 (LAM-1), CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) in Fibrotic Patients

Tamer E. Mosa, Mahmoud El-Sherbiny, Azza F. Arafa, Hisham A. Orban, Tarek E. Hodhod & Mostafa Abo-Zeid · Asian Journal of Research in Biochemistry · 2018

Leukocyte adhesion molecule-1 (LAM-1), CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1) are adhesion molecules and constitute important steps in the liver inflammation due to chronic hepatitis C. We measured soluble intercellular adhesion molecule (LAM-1), (LFA-1) and (Mac-1) as well as...

Open access Research Article 10.9734/ajrb/2018/v2i1386

Fatty Acids and Physicochemical Compositions of Dried and Roasted Blighia sapida Arils Oils (Ackee Apple) from Côte d’Ivoire

Armelle Moya Felarry Hoba, Yolande Dogoré Digbeu, Siaka Binate, Edmond Ahipo Dué & Lucien Patrice Kouamé · Asian Journal of Research in Biochemistry · 2018

In this work, comparative study of physicochemical properties and fatty acids of dried arils (DA) oil and those roasted (RA), of Blighia sapida from Côte d’Ivoire have been done using usual methods. The results showed that the crude fat obtained were 59.08± 0.02 g/100 g for dried...

Open access Research Article 10.9734/ajrb/2018/v2i1374

Effects of Ethanol Leaf and Fruit Extracts of Kigelia africana on Some Oxidative and Biochemical Parameters of Alloxan -Induced Diabetic Rats

E. N. Uhuo, L. U. S. Ezeanyika & V. N. Ogugua · Asian Journal of Research in Biochemistry · 2018

Hyperglycaemia, a characteristic feature of diabetics mellitus leads to decreased antioxidant defense and hence the development of oxidative stress, which is involved in the aetiology of development of diabetic complications. This work was therefore aimed at evaluating the anti d...

Open access Research Article 10.9734/ajrb/2017/v1i1366

Toxicological Evaluation of Two Named Herbal Remedies Sold Across Orumba South Local Government Area of Anambra State, South-Eastern Nigeria

S. I. Egba, J. O. Ogbodo, P. O. Ogbodo & C. A. Obike · Asian Journal of Research in Biochemistry · 2018

Aim: Herbs are plants or parts of plants used for their therapeutic, aromatic or savoury values. This work studied the potential sub-chronic toxic effects of Goko and BetaB, two herbal remedies used in treating human diseases and sold in Orumba Local Government Area of Anambra st...

Open access Research Article 10.9734/ajrb/2017/v1i1355