Aim: This work aimed to formulate self-nano emulsifying drug delivery systems (SNEDDS) for augmenting the biopharmaceutical performance of ibuprofen, a poorly-water soluble drug and subsequently evaluate its anti-inflammatory activity. Methodology: Pseudoternary phase diagram stu...
Open access
Research Article10.9734/JPRI/2018/43090
Aims: This study was conducted to investigate the antimicrobial activities of Sassafras albidum (Nutt.), Ehretia anacua (Terán & Berl.), Melissa officinalis (Linn.), Eysenhardtia texana (Scheele), and Melissa odorata. Specifically, this study aims to evaluate the antimicrobia...
Open access
Research Article10.9734/JPRI/2018/41205
In this study, removal of Tetracycline (TC) antibiotics from artificially contaminated water has been investigated with the aim of detoxifying pharmaceutical wastewater before their safe disposal onto land or into river waters. The adsorption of TC occurred by studying the effect...
Open access
Research Article10.9734/JPRI/2018/42583
Aim: A Large percentage of the Nigerian populace consumes herb concoction prepared by local vendors without due regard to quality control such as toxicity and validity testing. The present study assessed the toxicological effects of continuous intake of some locally prepare herbs...
Open access
Research Article10.9734/JPRI/2018/42002
Substance abuse among young people is a complex and a problematic social phenomenon which is growing steadily worldwide and family influences on it have been hypothesized from diverse research and theoretical perspectives. This paper focused on family influences on drug abuse ten...
Open access
Research Article10.9734/JPRI/2018/42708
Zohreh Sarhadinejad, Fariba Sharififar, Zarrin Sarhadynejad, Zohreh Salari, Haleh Tajadini, Farzaneh Mohamadi, Amir Asadi-Khanouki & Mehdi Ansari·Journal of Pharmaceutical Research International·2018
Background: Dill seed has been used as a vaginal discharge remedy according to traditional origins, but its application by traditional methods is difficult and time-consuming. Aims: The main aim of this study was preparing a vaginal dosage form with acceptable physicochemical pro...
Open access
Research Article10.9734/JPRI/2018/42143
Eleonora Okuskhanova, Maksim Rebezov, Zhanibek Yessimbekov, Diana Tazeddinova, Pavel Shcherbakov, Tatiana Bezhinar, Oksana Vagapova, Tatiana Shcherbakova & Marilyne Stuart·Journal of Pharmaceutical Research International·2018
Background: The formulation of new meat products requires evaluation of the effect of different ingredients on physical-chemical and rheological properties of meat batters. Objective: In this study, the yield stress properties of three low-calorie meat pâté recipes were evaluated...
Open access
Research Article10.9734/JPRI/2018/42317
Introduction: Stress-related mucosal disease (SRMD) occurs in many critically ill patients in Intensive Care Units (ICU) and may develop within 24 hours of admission. Proton pump inhibitors (PPI) therapy has been documented to produce more potent inhibition of gastric acid secret...
Open access
Research Article10.9734/JPRI/2018/39316
Aim: Aim of this research was to develop and validate a simple, efficient and reproducible high-performance liquid chromatography method to measure phenytoin concentrations in human plasma Study Design: Linearity, selectivity, sensitivity, accuracy and precision of the analytical...
Open access
Research Article10.9734/JPRI/2018/41885
Aims: Inflammation has been implicated in many disorders and currently available therapies elicit adverse effects. The coarse shrub of Calotropis procera has been used in folk medicine to treat several ailments such as asthma, rheumatism and also fever. The anti-inflammatory pote...
Open access
Research Article10.9734/JPRI/2018/42529
Vernonia amygdalina popularly called bitter leaf is used in traditional medicine to treat fever, malaria, diarrhoea, dysentery and diabetes. They serve as laxatives and fertility inducer. They are commonly used as vegetable. The effects of methanolic extract of Vernonia amygdalin...
Open access
Research Article10.9734/JPRI/2018/41908
Aim: This study investigated the acute toxicity (LD50) and antipsychotic potentials of ethanol leaf extract of Milicia excelsa (EME), hexane (HF), ethyl acetate (EAF), butanol (BF) and aqueous (AF) fractions in mice. Study Design: This study used experimental mice models predicti...
Open access
Research Article10.9734/JPRI/2018/42383
The present study was aimed at the in-vitro analysis of the antioxidant and antidiabetic potential of the methanol extracts of four perennial plants which are indigenous to Botswana and further to investigate whether their antihyperglycemic effects are working through the antioxi...
Open access
Research Article10.9734/JPRI/2018/42218
Background: Diclofenac is used as a potential analgesic for mild to moderately severe pain including migraine pain. However, the common side effect of this drug (drowsiness) becomes bothersome for patients taking diclofenac on regular basis in order to get rid of migraine pain. T...
Open access
Research Article10.9734/JPRI/2018/40988
The purpose of this study was to formulate and evaluate metoprolol tartrate (MT) loaded liposomes using factorial design. Preparation of niosomal drug delivery of MT increased its bioavailability which led to being better therapeutic effects, reduced the frequency of dosing and d...
Open access
Research Article10.9734/JPRI/2018/42068