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All published articles 581

Artificial Intelligence and Digital Therapy for Adolescent Mental Health in the UK: Opportunities, Barriers and Ethical Consideration

Kelechi Nelson Adindu, Nnaemeka AKUBUE, Nnorom Obioma JUDE, Ademola ONAKOYA, Chisom CHUKWUNONYE, Oisedebame ODION, Chinelo Grace OKENGWU, Nwudele Uchechukwu, Philip Zikora OSITA-OBASI, Adanna EZIKE, Ismail BELLO, Emmanuella OLENLOA, Oghenevbede Ogaga ERUTEYA & Sherriff Abiodun OYEWOLE · International Neuropsychiatric Disease Journal · 2025

Background: Adolescence constitutes a critical developmental stage marked by the onset of mental health difficulties, yet timely access to effective mental health care remains a significant challenge for many adolescents in the United Kingdom (UK). Artificial intelligence (AI)-en...

Open access Research Article 10.9734/indj/2025/v22i4498

Study on the Transition of Defense Mechanisms from a Healthy Frame of Mind to a Depressed Outlook on Life

Rudraksh Kesharwani, Soubhagya Ranjan Mohapatro, Ritika Agarkar, Shubhangi Nagpal, Rehan Ali, Angel Parul Luka & Anamika Sharma · International Neuropsychiatric Disease Journal · 2025

Aims: This study examines changes in various defense mechanisms as individuals transition from a healthy state of mind to a depressed state, as well as the prevalence of different defense mechanisms. Study Design: Hospital- and Community-Based Cross-Sectional Study Place and Dura...

Open access Research Article 10.9734/indj/2025/v22i4497

Expert Perspectives on the Use of Escitalopram in the Management of Depression and Anxiety Disorders in Indian Settings

Manjula S & Krishna Kumar M · International Neuropsychiatric Disease Journal · 2025

Background:  Though there are several studies on the efficacy of escitalopram in the management of depression and anxiety disorders, there is a dearth of studies among clinicians regarding their perspectives. This study assesses clinician preferences for escitalopram across vario...

Open access Research Article 10.9734/indj/2025/v22i4496

Relationship between Depression Scores, Sleep Quality, Chronotype and Cardiorespiratory Fitness among Undergraduate Health Students

Eduardo Fernandes de Miranda, Deyvison José da Silva, Rayane Cavenage Silva, Fernanda Martins Silva, Maria Clara de Almeida Souza, Helen Castro Dantas Rodrigues, Maisa Bruna de Morais Teixeira do Nascimento, Andressa Sena Rodrigues, Carina Souza de Melo, Daniela Leão da Costa, Laís Tonello & Iransé Oliveira-Silva · International Neuropsychiatric Disease Journal · 2025

Introduction: University students face challenges that impact both their physical and mental health. However, studies that integrate depressive symptoms, sleep quality, chronotype, and cardiorespiratory fitness remain scarce. Objective: This study aimed to analyze the relationshi...

Open access Research Article 10.9734/indj/2025/v22i4495

Effects of Psycho-Education on Substance Abuse-Literacy among Secondary School Students in Nigeria

Deborah Oluwadamilola Ilugbaro, Olukorede Patricia Adisa & Bayo Lawal Ajibade · International Neuropsychiatric Disease Journal · 2025

Background: The increasing rate of substance abuse and its adverse effects on physical and psychosocial health is a public health concern affecting adolescents. Psychoeducation has shown to be an effective treatment intervention in psychotherapy and patient education. This study...

Open access Research Article 10.9734/indj/2025/v22i4494

Beyond Dopamine: Exploring Novel Pharmacological Targets for Improved Antipsychotic Outcomes

Felix Keneolisa Asogwa, Daniel Lotanna Ajaghaku, Augustine Oluchukwu Asogwa, Levi Onyebuchi Idokoja, Detu Martins Ikpechukwu & Damian Chukwunonso Mbah · International Neuropsychiatric Disease Journal · 2025

Schizophrenia is a disorder characterized by a multifaceted pathogenic mechanism impacted by numerous genes. The investigation of its pathophysiology is mostly dominated by the dopamine hypothesis.  Multi-target therapies represent a viable strategy for addressing polygenic disor...

Open access Research Article 10.9734/indj/2025/v22i4492

Ekbom Syndrome : A Case Series from West Africa

OUEDRAOGO Rasmané, KOANDA Madina, COULIBALY Mohamed Ben Idriss, Cissé Almoustapha Ousmane, DOGA Abdoul-Azize, Nikiema P Alphonse, DANVIO Antoine, Djiguemdé K Jean, SALIFOU ABDOU Mahamane Mobarak, BAGUE Boubacar, KORSGA Nina & KARFO Kapouné · International Neuropsychiatric Disease Journal · 2025

Ekbom syndrome or delusional parasitosis is a rare disorder characterized by the unshakeable and fixed belief that the skin is infested by insects or parasites. It is a monothematic delusion of hallucinatory origin, which can affect men or woman independent the old. We report the...

Open access Research Article 10.9734/indj/2025/v22i4491

Memory Theory of Cortical Homunculus: A Review

Matthias OYIGEYA, Akindele AKINJOLA, Aladi EDEH & Ngosoo Perpetua CHIA · International Neuropsychiatric Disease Journal · 2025

Background & Aim: To express a perspective on cortical homunculus as a universal memory storehouse and control centre of an organism. The cortical homunculus, the “little human” in the brain is the internal representation of human body parts within the sensory and motor domai...

Open access Research Article 10.9734/indj/2025/v22i4490

From DNA to Doses: How Pharmacogenomics Transforms Depression Care in Community Pharmacy?

Momin Shabana, Nusrath Fatima, T. Kusuma Teja & Umar Zeshan · International Neuropsychiatric Disease Journal · 2025

Pharmacogenomic testing can identify these genetic variations, allowing healthcare providers to adjust drug selection and dosage accordingly. These tests typically involve a simple cheek swab or saliva sample, which is then analysed to identify specific genetic variations that af...

Open access Research Article 10.9734/indj/2025/v22i4489

Vitamin C and E Abrogate Myelin, Oligodendrocyte and Inflammatory Markers of Rohypnol Exposed Amygdala in Adult Rats

Joshua Izuchukwu ABUGU, Ezejindu Damian NNABUIHE, Enemuo IJEOMA, Doris Kasarachi Ogbuokiri, Agulanna Ambrose ECHEFULACHI, Darlington Kenechukwu EZEAGU, Sebastine Okechukwu Nwoko, Samuel Chukwudi Chime, Ebangah Ashutiku EGBEWATT, Eduitem Sunday Otong, Gerald Ekene APEH & Ovuoba Kenneth NWODOM · International Neuropsychiatric Disease Journal · 2025

Rohypnol, scientifically known as flunitrazepam, is a potent benzodiazepine medication primarily prescribed for the treatment of severe insomnia and as a pre-anesthetic medication. However, its reputation has been tarnished by its misuse as a recreational drug and its association...

Open access Research Article 10.9734/indj/2025/v22i3487

Effect of Cyberbullying and Cyberstalking in Youth: A Cross-Sectional Study Conducted at a Tertiary Care Hospital in Western India

Lakhan R Kataria, Nisheet M. Patel, Akansha Jain, Dhatri C. Sarvaiya & Prajesh M. Kalathiya · International Neuropsychiatric Disease Journal · 2025

Background: Cyberbullying and cyberstalking are emerging challenges, especially among youths, owing to the growing penetration of social media and digital platforms. Despite the global awareness of their psychological consequences, specific data from Gujarat, India, remains scarc...

Open access Research Article 10.9734/indj/2025/v22i4488

Bulimia Nervosa Causing Unknown Threat to Oral Health: A Comprehensive Review

Owen R. Thornton & Wenjun Li · International Neuropsychiatric Disease Journal · 2025

Bulimia nervosa (BN) is a severe psychiatric disorder characterized by recurrent episodes of binge eating followed by compensatory behaviors, such as self-induced vomiting, misuse of laxatives, and excessive exercise. The oral and dental repercussions of BN can be profound, and d...

Open access Research Article 10.9734/indj/2025/v22i3493

Crosstalk of the Neuronal Microenvironment in the Pathophysiology of Alzheimer's Disease and Prospective Intervention Strategies Advancing Mitochondrial Dynamics: A Comprehensive Review

Taslim Uddin & Rokeya Parven Srite · International Neuropsychiatric Disease Journal · 2025

Mitochondria play a fundamental role in cell bioenergetics and respiratory processes, both of which are necessary for the myriad of metabolic responses that sustain cellular vitality. Mitochondrial dysfunction in neuronal cells facilitates the generation of reactive oxygen specie...

Open access Research Article 10.9734/indj/2025/v22i3486

Climate Psychiatry: The Impacts of Climate Change Intergenerational Trauma's Impact on Reproductive, Neuropsychiatric and Neurodegenerative Disorders

Kimberly Morton Cuthrell · International Neuropsychiatric Disease Journal · 2025

Climate change is an inexorable global phenomenon with far-reaching implications for mental and physical health as well as biodiversity. Extreme weather patterns, including natural disasters, account for a wide-range of reproductive, neuropsychiatric, and neurodegenerative condit...

Open access Research Article 10.9734/indj/2025/v22i3483

Examining the Moderating Role of Mindfulness in the Relationship between Workplace Stressors and Subjective Well-being

Antonas Dembickis · International Neuropsychiatric Disease Journal · 2025

Aims: This study examined the impact of workplace stressors on employees’ subjective well-being and evaluated the mediating role of coping strategies and the moderating role of mindfulness within this relationship. Study Design: A cross-sectional quantitative survey design was em...

Open access Research Article 10.9734/indj/2025/v22i3484