Comparison of In-Hospital Outcome of Acute Myocardial Infarction in Patients with vs without Diabetes Mellitus in Durres Population

Abstract

Background: Diabetes mellitus (DM) is a worldwide epidemic and a major public health problem and the mortality of diabetic patients is twice higher than that of with non-diabetic patients. The in-hospital outcomes in diabetic patients with acute myocardial infarction (AMI) are less known in Albania. Aim: To compare in-hospital outcomes of AMI in diabetic vs non-diabetic patients in Albania. Methods: A prospective, observational study. Patients with AMI between September 2012 and October 2014 were involved in the current study. Traditional risk factors for CAD, serum creatinine levels, and coronary angiographic results were recorded. In-hospital mortality of patients with and without DM was compared. P value of <0.05 was considered statistically significant. Results: From 420 enrolled patients with AMI, 281 (66.9%) were with DM, and 139 (33.1%) were non-diabetic. Baseline hypertension and cerebral vascular disease were more prevalent in diabetic than in non-diabetic patients. Diabetic patients also demonstrated a higher mean serum creatinine level than non-diabetic individuals (creatinine: 2.3±1.24 vs1.76±0.98 mg/dl P<0.05). Older age, multi-vessel diseases, poor renal function and higher killip class were associated with in-hospital mortality in patients with AMI. In-hospital mortality was higher in diabetic than non-diabetic patients (13.7% vs.7.9%, P<0.05). Conclusion: The present study suggests that in Albania, the in-hospital mortality rate in diabetic patients with AMI was higher than that in non-diabetic patients, which may be related to more comorbidies in diabetic patients. Hence, early aggressive treatment in the course of diabetic patients with acute AMI is important.